Tadalafil

CMOAPI ili ndi zida zonse zopangira Tadalafil, ndipo ili ndi kachitidwe kazomwe amayang'anira.

Kuwonetsa zotsatira zonse 3

Kodi Tadalafil ndi chiyani

Tadalafil ndi mankhwala omwe amagwiritsidwa ntchito pochiza kuwonongeka kwa erectile (ED) ndi zizindikiro za kukulitsa kwa prostate mwa amuna. Amasonyezanso kuti amachiza matenda oopsa a m'mapapo (PAH).
Tadalafil (Nambala ya CAS: 171596-29-5) imapezeka ngati piritsi kapena pakamwa pa tadalafil ndipo imagulitsidwa kwambiri pansi pa dzina loti Cialis (ya erectile dysfunction kapena benign prostate kukulitsa) kapena Adcirca (ya pulmonary arterial hypertension). Tadalafil imapezekanso mu mawonekedwe ake omwe sangakhale ndi mphamvu zonse monga kapangidwe koyambirira


Kodi tadalafil imagwira ntchito bwanji?

Tadalafil ndi imodzi mwa zoletsa za phosphodiesterase mtundu wa 5 (PDE5). Magulu awa azida akaletsa PDE5 nawonso amalimbikitsa kugwira ntchito kwa erectile.
Pa nthawi yogonana, erection imachitika pakakhala magazi okwanira m'mitsempha ya penile yomwe imabweretsa mitsempha yotakasuka komanso minofu yosalala ya corpus cavernosum. Kuyankha uku kumayang'aniridwa ndikupanga nitric oxide (NO) m'maselo endothelial ndi malo amitsempha. Kutulutsidwa kwa NO kumathandizira kuphatikizika kwa cyclic guanosine monophosphate (makamaka kotchedwa cyclic GMP kapena cGMP) m'maselo osalala a minofu. Ma cyclic GMP amathandizira kupumula minofu yosalala ndikuwonjezera magazi ku corpus cavernosum.
Tadalafil imaletsa phosphodiesterase mtundu wa 5 (PDE5) powonjezera kuchuluka kwa cGMP. Ndikoyenera kudziwa kuti munthu ayenera kukhala ndi chilakolako chogonana kuti ayambe kutulutsa nitric oxide. Izi ndichifukwa choti zotsatira za Tadalafil sizingachitike popanda kukakamiza kugonana.
Tadalafil imatha kuchepetsa zizindikilo za zotupa za prostate zokulitsidwa kuphatikiza kukodza mwachangu / pafupipafupi, kuvuta, komanso kusadziletsa kwamikodzo. Zimakwaniritsa izi pofewetsa minofu ya prostate ndi chikhodzodzo.
Mu pulmonary hypertension, tadalafil imathandizira kupumula mitsempha yamagazi pachifuwa. Izi zimathandizanso kukulitsa kupezeka kwa magazi m'mapapu komanso kumachepetsa ntchito yamtima.


Othandizira a Tadalafil

Pokonzekera tadalafil (CAS 151596-29-5), nkhoswe zina zimapangidwa. Makampani ena amagwiritsa ntchito tadalafil intermediates kuti apange tadalafil.

Nkhani 171596-29-5

Tadalafil (CAS 171596-29-5) ndi mankhwala othandiza komanso othandiza pochiza matenda osokoneza bongo ndi kukulitsa kwa prostate mwa amuna komanso mitsempha ya m'mapapo magazi.

Nkhani 171489-59-1

Cas 171489-59-1 yomwe imadziwikanso kuti Chloropretadalafil ndiyapakatikati popanga Tadalafil yomwe imagwiritsidwa ntchito pochiza kuwonongeka kwa erectile. CAS 171489-59-1 ili ndi molekyulu yofanana ndi C22H19ClN2O5 yokhala ndi kulemera kwa 426.85 g / mol. Ikupezeka ngati choyera choyera.

Nkhani 171752-68-4

CAS 171752-68-4 yomwe mawonekedwe ake ndi C20H18N2O4.HCl ndi kulemera kwake kwa 386.83 g / mol ndi tadalafil wapakatikati.
Pali ambiri omwe amagulitsa ma tadalafil omwe amapereka pakati pamalonda pamitengo yampikisano. Komabe, mukaganiza kuti tadalafil igule kuchokera kumakampani odalirika kuti muwonetsetse kuti mulibe zinthu zabwino.
CMOAPI ndi m'modzi mwa ogulitsa tadalafil apakatikati omwe amatsimikizira mitengo yawo yabwino komanso mpikisano.


Ndani ndi momwe mungagwiritsire ntchito tadalafil

Tadalafil ufa amatha kuthana ndi izi mwa amuna?

Kusokonekera kwa Erectile

Kulephera kwa Erectile (ED) komwe kumatchedwanso kusowa mphamvu ndi vuto mwa amuna momwe sangathe kupeza kapena kusunga erection nthawi yokwanira yochita zogonana. Nthawi zambiri zimabweretsa chidwi pa zogonana ndipo zimatha kubweretsanso zovuta zina monga kuchepa msanga kapena kuchedwa kukodzera komanso nthawi zina kulephera kufikira pamalungo.
ED imatha kuyambitsidwa ndi zifukwa zambiri zakuthupi ndi zamaganizidwe monga matenda ena monga matenda ashuga, matenda amtima, matenda oopsa, ukalamba, kupsinjika, kapena ngakhale ubale.
Tadalafil imathandizira kuchiza ED pakukulitsa magazi kutuluka mbolo. Izi zimathandizanso kukwaniritsa ndikusunga erection. Komabe, tadalafil imangothandiza pakumangirira pomwe wina ali ndi chilakolako chogonana.

Benign Prostatic hyperplasia (BPH)

Amatchedwanso kukulitsa kwa Prostate gland, BPH ndichizoloŵezi chofala chomwe chimapezeka mwa amuna atakalamba. Komabe, zinthu zina zingapo zitha kubweretsa kukulira kwa Prostate kuphatikiza matenda ashuga komanso matenda amtima, moyo, makamaka kunenepa kwambiri komanso mbiri yabanja ya BPH. Prostate ikakulira imatha kudzetsa mkodzo.
Zizindikiro zomwe zimakhudzana ndi kukula kwa prostate gland ndizo, kufunikira mwachangu komanso pafupipafupi kukodza, kumakhala kovuta kuyamba kukodza, mkodzo wofooka, kapena kulephera kutulutsa chikhodzodzo kwathunthu. Zizindikiro zina za BPH zitha kuphatikizira matenda amkodzo (UTI), osatha kukodza, kapena magazi mkodzo.
Tadalafil ufa kapena piritsi imathandizira kupumula minofu mu prostate ndi chikhodzodzo. Izi zimathandiza kuthetsa zizindikiro za BPH.

Mitsempha yamagazi yamagazi (PAH)

PAH ndimkhalidwe womwe mumakhala kuthamanga kwa magazi m'mitsempha yomwe imapereka magazi kumapapu. Ndizosiyana ndi kuthamanga kwa magazi. Zimachitika pamene mitsempha yochokera kumtima mpaka kumapapo imakhala yopapatiza kapena yotseka.
Zizindikiro zodziwika bwino ndizopweteka pachifuwa, kutopa, kapena kutupa m'miyendo mwanu.
Tadalafil itha kuthandiza kuthetsa zizindikiritso za PAH pochepetsa mitsempha yamagazi m'mapapu yomwe imawonjezera motsatana magazi.

Momwe mungagwiritsire ntchito tadalafil?

Mlingo wa tadalafil umadalira msinkhu wanu, momwe mungagwiritsire ntchito, komanso zovuta zina zamankhwala.
Kugwiritsa ntchito Tadalafil sikuvomerezeka kwa ana osakwana zaka 18 komanso okalamba kupitirira zaka 65 ayenera kukhala osamala chifukwa matupi awo amatenga nthawi yayitali kuti amwe mankhwalawa.
Pali malangizo omveka bwino amomwe mungagwiritsire ntchito tadalafil powder koma mawonekedwe ofala kwambiri ndi piritsi la tadalafil lomwe lili ndi mayina osiyanasiyana.
Ndikofunika kutenga tadalafil kamodzi tsiku lililonse ndikuzitenga nthawi yofananira tsiku lililonse kuti mupindule ndi tadalafil.
Mlingo wa tadalafil wa ntchito zosiyanasiyana umatanthauzidwa;
Kulephera kwa erectile, mlingo wa 2.5-5 mg umatengedwa tsiku lililonse kapena 10 mg mukamutenga kamodzi pakufunika.
Kwa benign prostatic hyperplasia, mlingo wa 5 mg womwe umatengedwa tsiku lililonse umalimbikitsidwa. Tadalafil iyenera kutengedwa kamodzi tsiku lililonse.
Pochita zinthu zonsezi (kuwonongeka kwa erectile ndi prostate wokulitsa) mlingo wa 5 mg patsiku ndi woyenera.
Ndi pulmonary arterial hypertension, mlingo wa tadalafil wa 40 mg womwe umatengedwa tsiku lililonse umanenedwa.
Monga mankhwala ena, zomwe zimagwirira ntchito wina sizingachitenso chimodzimodzi kwa wina. Njira zina za Tadalafil zilipo. Komabe, chinthu chabwino kwambiri kuchita ndikulankhula ndi dokotala za njira zomwe zilipo pa tadalafil ndikuwona zomwe zikukuyenererani. Mutha kulangizidwa kuti mutenge njira zina za tadalafil ngati muli ndi vuto la tadalafil kapena pazifukwa zina.
Ndiudindo wanu kuzindikira zomwe zikukuyenderani bwino mukamayesa kuti tadalafil ndiye chisankho kapena zoyipa za tadalafil zothetsera phindu la tadalafil.


Pali kusiyana kotani pakati pa Tadalafil ndi mankhwala ena osagwira bwino ntchito

Cialis (Tadalafil)

Cialis ndi mankhwala akuchipatala m'kalasi la mankhwala otchedwa Phosphodiesterase-5 Enzyme Inhibitors. Amagwiritsidwa ntchito kuthana ndi zizindikilo za kuwonongeka kwa erectile. Itha kugwiritsidwa ntchito payokha kapena kuphatikizidwa pamodzi ndi mankhwala ena.

Dapoxetine Hydrochloride

Dapoxetine hydrochloride amadziwika kuti ndi serotonin reuptake inhibitors (SSRIs) yosankha mwachangu.
Dapoxetine hydrochloride ndi mankhwala olembetsedwa omwe amagwiritsidwa ntchito pochiza kukodzera msanga. Kutulutsa msanga msanga ndichizoloŵezi chodziwika kwambiri mwa amuna chomwe chimaphatikizapo kulephera kuchedwa kukodzera. Ichi ndi chizindikiro chimodzi cha kulephera kwa erectile mwa amuna.
Ngakhale tadalafil ndi dapoxetine hydrochloride amagwiritsidwa ntchito kuthana ndi vuto la kuwonongeka kwa erectile, tadalafil imodzi ndi phosphodiesterase inhibitor pomwe inayo, dapoxetine, ndi serotonin reuptake inhibitor yosankha.

Vardenafil Hydrochloride

Vardenafil ndi mankhwala mgulu la mankhwala otchedwa phosphodiesterase (PDE) inhibitors. Amagwiritsidwa ntchito pochiza kukanika kwa amuna erectile. Mwamuna akagalamuka, vardenafil imakulitsa kutuluka kwa magazi kupita ku mbolo komwe kumakupangitsani kuti mukhale ndi vuto.
Vardenafil yogulitsidwa pansi pa dzina la Levitra imasankha kwambiri kuposa sildenafil ndi tadalafil (Cialis) kupita ku PDE5. Izi zimangotanthauza kuti mlingo wochepa wa vardenafil umafunika ndi zovuta zochepa.
Kusiyananso kwina kuli mu theka la moyo pomwe vardenafil (Levitra) amakhala ndi theka la maola 4-6 pomwe tadalafil (Cialis) ili ndi theka la maola 17.5. Izi zikutanthauza kuti Tadalafil (Cialis) imagwira ntchito nthawi yayitali kuposa vardenafil.

Avanafil

Avanafil ndi mankhwala mgulu la phosphodiesterase inhibitors. Amagwiritsidwanso ntchito kuthana ndi vuto la erectile posintha magazi m'dera la penile.
Ngakhale onse avanafil ndi tadalafil ndi phosphodiesterase inhibitors, avanafil ndiye watsopano kwambiri ndipo amakhala ndi theka lalifupi la maola 5 kuposa tadalafil yomwe ili ndi theka la maola 17.5.
Pomaliza, tadalafil ndiyabwino kwambiri chifukwa chotalikirapo theka. Wina atha kumwa mankhwalawa chifukwa cha zovuta zina zomwe zingachitike.


Tadalafil zoyipa ndi zabwino zake

Tadalafil amapindula

Ambiri omwe amaganiza zogwiritsa ntchito tadalafil powder amagula chifukwa cha zabwino zake za tadalafil;

Kuthetsa kusokonekera kwa erectile

Kukonzekera kwa Penile ndichinthu chofunikira kwambiri pakugonana. Kulephera kwa Erectile kumachitika ngati munthu sangathe kupeza erection. Izi zimayambitsa zovuta zambiri monga kupsinjika, kunyozeka, komanso mavuto amgwirizano.
Kukhazikika kumachitika pakakhala magazi okwanira mbolo. Tadalafil imathandizira kuthetsa zizindikilo za kuwonongeka kwa erectile powonjezera kuthamanga kwa magazi kupita ku mbolo.

Kuchiza zizindikiro za benign prostatic hyperplasia

Benign Prostatic hyperplasia amatchedwanso kukula kwa Prostate gland. Izi ndizomwe zimachitika mwachilengedwe ndi msinkhu. Pamene prostate imakula, imafinya mkodzo. Zina mwazizindikiro zomwe zimakhudzana ndi prostate yokulitsidwa ndi; kukodza mwachangu komanso pafupipafupi, kumakhala kovuta kuyamba kukodza, kupweteka pokodza pakati pa ena.
Tadalafil imapindulitsa amuna omwe ali ndi vuto la benign prostatic hyperplasia pothetsa izi. Tadalafil ufa amathandizira kupumula prostate gland komanso chikhodzodzo motero kumachepetsa zizindikilo zomwe zimakhudzana ndi chikhodzodzo choponderezedwa ndi urethra.

Amatha kuthana ndi vuto lililonse la erectile komanso benign prostatic hyperplasia

Tadalafil ikhozanso kuthandizira amuna omwe ali ndi vuto la kuwonongeka kwa erectile komanso kukulitsa kwa prostate nthawi imodzi.
Mukamagwiritsa ntchito tadalafil pamlingo woyenera komanso monga momwe mumalangizira mumapeza zabwinozo. Popeza ndimalimbikitsa kutuluka kwa magazi mdera la penile komanso madera ena, ndi njira yothanirana ndi izi.

Itha kugwiritsidwanso ntchito pochiza matenda am'magazi oopsa

Kuthamanga kwa magazi m'mapapo (PAH) kumatanthauza kuti pali kuthamanga kwa magazi m'mitsempha yomwe imatenga magazi kuchokera pamtima kupita m'mapapu. Komabe ndizosiyana ndi kuthamanga kwa magazi pafupipafupi.
PAH imachitika pamene mitsempha yomwe imapereka magazi m'mapapu imakhala yopapatiza kapena yotsekedwa zomwe zimapangitsa mtima kukakamizidwa kupopa magazi pamlingo wokwera. Kugunda kwamtima mwachangu komanso mokakamiza kumeneku kumapangitsa kukakamizidwa kwambiri pamitsempha.
Tadalafil ufa umadabwitsa ndikutsitsimutsa mitsempha yamagazi. Kupumula uku kumapangitsa kuti magazi aziyenda bwino motero kumakulitsa kuchuluka kwa kuyenda. Izi zimathandiza mtima kutulutsa magazi mosalaza motero kuthana ndi vuto lomwe likadapezekanso

Zimakuthandizani kuti muzitha kuchita masewera olimbitsa thupi

Mukamachita masewera olimbitsa thupi ndikofunikira kuti munthu alandire mpweya wokwanira komanso kuti apange mphamvu zokwanira zofunika.
Tadalafil imatha kulimbitsa thupi lanu pochita kupumitsa mitsempha yanu ndikuwonjezera magazi.

Zotsatira zoyipa za Tadalafil

Zotsatira zofala kwambiri za tadalafil ndizo;

  • Mutu,
  • Nseru,
  • kutentha (kutentha, kufiira, kapena kumva kwakanthawi),
  • kukhumudwa m'mimba,
  • yothina kapena yothamanga mphuno, ndi
  • kupweteka kwa minofu, kupweteka kwa msana, ndi kupweteka m'manja kapena miyendo yanu.

Tadalafil amathanso kubweretsa zovuta zina. Mukulangizidwa kuti mupite kuchipatala ngati mungakumane ndi zotsatirazi:

  • Zizindikiro zina za mtima zomwe zimaphatikizapo kupweteka pachifuwa, kupweteka kufalikira ku nsagwada kapena paphewa, nseru, ndi thukuta.
  • masomphenya amasintha kuphatikiza kusawona bwino kapena kutaya mwadzidzidzi.
  • kutentha (kutentha, kufiira, kapena kumva kwakanthawi),
  • Kumva kuwonongeka mu
  • kulira m'makutu mwanu ndikumva kwakumva
  • Erection yomwe imapweteka kapena imatenga nthawi yayitali kuposa maola 4 chifukwa izi zitha kuwononga mbolo yanu.
  • kusanza
  • Kuphatikizika kwa mtima
  • Kukomoka, chizungulire komanso,
  • Kutopa kwachilendo.

Kuyanjana kwa Mankhwala a Tadalafil

Zochitika zingapo za tadalafil ndi mankhwala ena zidanenedwapo. Kuyanjana kwa mankhwala nthawi zambiri kumasintha magwiridwe antchito amankhwala ndipo kumatha kulepheretsa mankhwalawo kuti agwire bwino ntchito.
Ndikulangizidwa kwambiri kuti mukambirane za mankhwala anu musanagwiritse ntchito tadalafil. Kuyanjana kwina kwa tadalafil kumatha kukhala kofatsa komanso kovuta.
Pansipa pali kulumikizana kwa tadalafil;

Nitrates

Amatchulidwanso kuti mankhwala a Anguina. Ma nitrate akatengedwa limodzi ndi tadalafil, zimatha kuyambitsa kuthamanga kwa magazi kutsikira kutsika kwambiri. Kuchepetsa kuthamanga kwa magazi kumalumikizidwa ndi zizindikilo monga chizungulire kapena kukomoka.
Zina mwazowawa za mankhwalawa ndi monga; butyl nitrite, amyl nitrite, isosorbide dinitrate, nitroglycerin, ndi isosorbide mononitrate.

Alpha-blockers

Awa ndi mankhwala omwe amagwiritsidwa ntchito pokonza kuthamanga kwa magazi. Amagwiritsidwanso ntchito pochiza prostate. Onse awiri a tadalafil ndi alpha-blockers ndi ma vasodilator omwe amakhala ndi vuto lochepetsa kuthamanga kwa magazi. Mukazigwiritsa ntchito limodzi, zimatha kutsitsa kwambiri magazi. Izi zimapangitsa kuti munthu akhale ndi chizungulire komanso amatha kukomoka.
Ena mwa mankhwala a alpha-blockers ndi awa; terazosin, tamsulosin, alfuzosin, ndi prazosin.

Mankhwala ena a HIV

Mankhwalawa ndi ma protease inhibitors motero amatha kuwonjezera kuchuluka kwa tadalafil m'magazi. Kuchulukaku kumabweretsa kuthamanga kwa magazi. Zitha kupanganso kukondera mwa amuna zomwe zikutanthauza kuti amapeza erection yayitali yomwe nthawi zambiri imakhala yopweteka.
Ena mwa mankhwalawa ndi ritonavir ndi lopinavir.

Maantibayotiki

Kuyanjana kwa Tadalafil ndi maantibayotiki kunanenedwa. Akaphatikizidwa ndi tadalafil, maantibayotiki amatha kuwonjezera mulingo wa tadalafil m'magazi omwe amatsogolera kutsika kwa magazi. Zitha kutulutsa chizungulire, kukomoka, ngakhale masomphenya ena. Ikhozanso kuyambitsa kukondera mwa amuna.
Ena mwa mankhwalawa ndi erythromycin, telithromycin, ndi clarithromycin.
Komabe, maantibayotiki ena amatha kutsitsa tadalafil m'magazi. Kuyanjana kwa tadalafil sikugwira bwino ntchito. Mankhwalawa akuphatikizapo; rifampin.

Mankhwala osokoneza bongo

Mankhwala ena am'kamwa kuphatikiza ketoconazole ndi itraconazole amalumikizana ndi tadalafil.
Mankhwalawa amatha kukweza tadalafil yomwe imabweretsa chizungulire komanso kukomoka zitha kuchitika.

Mankhwala ena oopsa a m'mapapo mwanga

Tadalafil ndi mankhwala ena am'mapapo mwazi amadziwikanso kuti amachepetsa kuthamanga kwa magazi. Mukagwiritsidwa ntchito limodzi zimatha kuyambitsa kuthamanga kwa magazi. Izi zimapangitsa kuti azikhala ndi vuto lotsika magazi monga chizungulire komanso kukomoka.
Mankhwalawa akuphatikizapo riociguat.

Maantacid

Mankhwalawa amagwiritsidwa ntchito kuthetsa asidi am'mimba. Pogwiritsidwa ntchito limodzi ndi tadalafil, zitha kulepheretsa kuyamwa kwa tadalafil mthupi. Mulinso magnesium hydroxide kapena aluminium hydroxide.

Mankhwala a khunyu

Izi zimatchedwanso mankhwala oletsa kulanda. Mukamwa mankhwala osokoneza bongo pamodzi ndi tadalafil, amatha kuchepetsa kuyamwa kwa tadalafil. Izi zikutanthauza kuti tadalafil sichitha kugwira bwino ntchito. Mankhwalawa akhunyu amaphatikizapo phenytoin, phenobarbital, ndi carbamazepine.


Mungagule kuti Tadalafil?

Mutha kupanga Tadalafil kugula m'masitolo apaintaneti. Ufa umapezeka wochuluka kwa ofufuza ndi akatswiri. Onetsetsani kuti mwayang'ana tadalafil powder ovomerezeka ogulitsa Mukamaganiza zogwiritsa ntchito tadalafil mugule kwa ogulitsa odalirika.
Funsani dokotala musanatenge tadalafil chifukwa cha zovuta za tadalafil komanso kulumikizana kwa tadalafil ndi mankhwala ena.
Ngati mukuyang'ana Tadalafil kapena oyimira pakati, muyenera kufunsa ndi CMOAPI kuti mupeze zogulitsa zenizeni. Makampani athu adalimbikitsidwa.


Zothandizira
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  2. "FDA Yalengeza Zosinthidwa Pamakalata a Cialis, Levitra ndi Viagra". US Food and Drug Administration (FDA). 2007-10-18. Zosungidwa kuchokera pachiyambi pa 2016-10-22. Kubwezeretsedwa 2009-09-28.
  3. "Cialis tadalafil PI". Chithandizo Cha Katundu Wothandizira. Kubwezeretsedwa 2020-08-19.
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