Avanafil

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Chidziwitso cha Base cha Avanafil

dzina	Avanafil ufa
Zofuna	White powder
Cas	330784-47-9
Assay	≥99%
Kutupa	nsoluble m'madzi kapena mowa, sungunuka mu Acetic acid, ethyl ester.
Kulemera kwa maselo	483.95g / mol
Melt Point	150-152 ° C
Molecular Formula	C23H26ClN7O3
Mlingo	100mg
Nthawi yoyamba	30minutes
kalasi	Maphunziro a Zamankhwala

 

Ndemanga ya Avanafil

Kodi mumadziwa kuti amuna opitilira 30 miliyoni ku United States ali ndi vuto la erectile (ED)? Izi ndichifukwa chake pali mankhwala ambiri a ED omwe amagulitsidwa ku US. Imodzi mwa mankhwalawa ndi avanafil. Stendra ndiye dzina la avanafil kuti mudziwe bwino.

Chimamanda Ngozi Adichie (Stendra) ndi PDE-5 (phosphodiesterase-type 5) inhibitor yomwe imatseka PDE-5.

Mukamamwa mankhwalawa, amatsitsimutsa mitsempha ndi mitsempha ina m'thupi lanu kukuthandizani kuti mukhale ndi erection powonjezera magazi kulowa mbolo yanu. Pachifukwa ichi, amagwiritsidwa ntchito pochiza matenda ophera erectile (ED). Monga Levitra® (vardenafil), Cialis® (tadalafil), ndi Viagra® (sildenafil), avanafil zidzakupangitsani kukhala kosavuta kuti mumange ndikukhazikika kwa kanthawi.

Avanafil (Stendra®) ndiyatsopano, yapangidwa m'ma 2000 ndi Mitsubishi Tanabe Pharma ku Japan. United States Food and Drug Administration (FDA) idavomereza mankhwalawa mu Epulo 2012 kuti amuthandize ED, pomwe European Medicines Agency (EMA) idavomereza mu June 2013.

Kuchokera kwa ambiri ndemanga za avanafil, mudzazindikira kuti ili ndi zovuta zochepa poyerekeza ndi Levitra, Cialis, Viagra, ndi mankhwala ena a ED.

Tiyeni tikumbe mozama kuti tidziwe zambiri za mankhwalawa.

 

Momwe Avanafil Amathandizira Kusokonekera kwa Erectile

Avanafil amagwiritsidwa ntchito pochiza ED kapena kusowa mphamvu, komwe kumatanthauza kulephera kupeza ndi kusunga erection. Avanafil amagwera m'gulu la mankhwala omwe amaletsa phosphodiesterase.

Dziwani kuti kuti mukhale ndi erection, mitsempha yanu yama penile imadzazidwa ndi magazi. Izi zimachitika pamene kukula kwamitsempha yamagazi kumakulirakulira, potumiza magazi ambiri ku mbolo yanu. Nthawi yomweyo, kukula kwa mitsempha yamagazi yochotsa magazi kuchokera ku mbolo yanu kumachepa motero kuonetsetsa kuti magazi amakhala mumisempha yanu ya penile, ndikupangitsa kuti pakhale nthawi yayitali.

Mukalimbikitsidwa ndi kugonana, muyenera kupeza erection. Kukula kumeneku kumapangitsa kuti mbolo yanu itulutse nitric oxide, chophatikiza chomwe chingapangitse guanylate cyclase (enzyme) kutulutsa cGMP (cyclic guanosine monophosphate), mthenga wofunikira wama cellular womwe umawongolera zochitika zambiri za thupi.

Kwenikweni, ndi cyclic nucleotide iyi yomwe imayambitsa kupumula ndi kupindika kwa mitsempha yamagazi yomwe imanyamula magazi kuchokera komanso kupita ku mbolo kuti ikonzeke. Enzyme ina ikawononga cGMP, mitsempha ya magazi imayambiranso kukula kwake koyambirira komwe kumayambitsa magazi kutuluka mu mbolo, ndipo izi ziziwonetsa kutha kwa erection.

Mukatenga avanafil, idzaletsa PDE-5 kuwononga cGMP, kutanthauza kuti cGMP ikhala motalikirapo ndikukhalitsa. CGMP ikakhala nthawi yayitali, magazi amatenga nthawi yayitali mbolo yanu ndikumangika kwanu kumatenga nthawi yayitali.

 

Kodi Avanafil (Stendra) Ndi Yothandiza Pothana ndi Kulephera Kwa Erectile?

Ngakhale avanafil (Stendra) ndi mankhwala atsopano a ED, maphunziro ambiri amatsimikizira kuti ndi othandiza pamankhwala a ED. M'maphunziro ena asanu omwe adachitika mu 2014 kuti adziwe ngati mankhwalawa ndi othandiza, amuna opitilira 2,200 adatenga nawo gawo, ndipo onse anali ndi vuto la erectile.

Pamapeto pa maphunziro, avanafil adapezeka kuti ndi othandiza kwambiri pakukonzanso IIEF-EF, index yapadziko lonse lapansi yomwe imagwiritsidwa ntchito kuwunika zovuta zokhudzana ndi zosokoneza.

Amuna onse omwe amamwa mankhwalawa adawonetsa kusintha kwakukulu mu IIEF-EF yawo pamiyeso kuyambira 50 mpaka 200mg. Zotsatira zakufufuzaku zikuwonetsanso kuti avanafil inali yothandiza kwambiri pamlingo waukulu wa 200mg. Izi zimasiyanitsa avanafil ndi mankhwala ena a ED omwe amayambitsa zovuta pamlingo waukulu.

Pakafukufuku wina wopangidwa mu 2012, avanafil adapezeka kuti amalekerera komanso amathandiza kwambiri pakuthandizira ED. Amuna awiri mwa omwe adachita nawo kafukufukuyu adawonetsa kusintha kwakukulu pakati pa 100 mpaka 200mg.

M'mayesero azachipatala okhudzana ndi avanafil, ofufuza adawonetsa kuti zikuwonetsa kulimbikitsidwa kwakukulu pamitundu yonse yokhudzana ndi ED. Mayesowa adakhudza amuna opitilira 600 azaka 23 - 88.

Mwachidule, avanafil imagwira bwino ntchito yothandizira ED. Kafukufuku wowerengeka watsimikizira kuti zitha kupanga kusintha koyezeka komanso kwakukulu pakukonzekera kwa amuna onse omwe ali ndi ED, mosasamala zaka zawo.

 

Zomwe zili Bwino Avanafil kapena Tadalafil?

Avanafil ndi mankhwala atsopano a ED pamsika, koma amachita bwino kuposa mankhwala akale a ED. Onse Avanafil kapena Tadalafil amagwiritsidwa ntchito kuthana ndi vuto la erectile, koma ali ndi zosiyana pamachitidwe awo.

Ngakhale tadalafil (Cialis) ndi mankhwala othandiza pakukula kwa prostate komanso kuwonongeka kwa erectile, Stendra nthawi zambiri amakhala woyamba kusankha kwa omwe ali ndi vuto la erectile.

 

Avanafil vs Tadalafil: Ndi iti yomwe imagwira ntchito mwachangu?

Tadalafil ndi mankhwala ena osokoneza bongo a m'badwo woyamba amatenga pakati pa mphindi 30 mpaka ola limodzi kuti zotsatira zawo zimveke. Ndipo nthawi zina, mutadya china cholemera, mankhwalawa amatha kutenga ola limodzi kuti ayambe kugwira ntchito. Izi sizili choncho ndi avanafil.

Mukatenga pakati pa 100 - 200mg ya malonda, mumva zotsatira za avanafil pasanathe mphindi 15. Kutanthauza kuti mutha kutenga mphindi zochepa musanayambe kugonana. Ngakhale mutatenga mlingo wochepa wa avanafil, nenani 50mg, mupezabe erection mkati mwa mphindi 30.

 

Avanafil vs Tadalafil: Ndi iti yomwe ili ndi zoyipa zochepa?

Ngakhale avanafil ali ndi zovuta zina, zotsatirazi sizochuluka ngati za tadalafil. Pulogalamu ya zotsatira za avanafil Komanso sizowopsa ngati za tadalafil. Mwachitsanzo, avanafil sikuyenera kuyambitsa kutsika kwa magazi ndikuwonongeka; Zotsatira zoyipa zomwe zimakhudzana ndi tadalafil ndi mankhwala ena a ED.

Ubwino wina wa avanafil ndikuti amatha kumwedwa pamlingo waukulu popanda kuyambitsa zovuta zilizonse. M'malo mwake, kuchuluka kwakukulu mpaka 200mg kumatha kutengedwa osadandaula za zovuta zilizonse.

Avanafil amachita mosiyana ndi tadalafil chifukwa imayang'ana mtundu wa 5 wa phosphodiesterase, osagwiritsa ntchito ma enzyme ena a phosphodiesterase monga PDE11, PDE6, PDE3, ndi PDE1.

 

Avanafil Sakukhudzidwa Ndi Chakudya.

Tadalafil ndi mankhwala ena osokoneza bongo a m'badwo woyamba nthawi zambiri amakhala osagwira ntchito atatha kudya chakudya chambiri chokhala ndi mafuta ambiri. Izi zimapangitsa kukhala kovuta kwambiri kuzigwiritsa ntchito popeza muyenera kuwunika momwe mumadyera komanso kukhala ndi chidwi ndi zomwe mumadya.

Kumbali inayi, avanafil samakhudzidwa ndi chakudya chomwe chimadyedwa, kutanthauza kuti mudzasangalala ndi zotsatira za avanafil ngakhale mutadya nthawi yanji komanso zomwe mumadya. Pachifukwa ichi, ndibwino kudya zakudya zamagetsi musanagwiritse ntchito mankhwalawa kuti mukhale ndi mphamvu zokwanira zogonana.

 

Avanafil vs Tadalafil: Ndi iti yomwe ingagwiritsidwe ntchito ndi mowa?

Ndikofunika kuti muchepetse kapena kupewa mowa mukamamwa mankhwala a tadalafil. Tadalafil imadziwika kuti imachepetsa kuthamanga kwa magazi, chifukwa chake kumamwa pamodzi ndi mowa kumatha kutsitsa kuthamanga kwa magazi kuti kukhale kovuta.

Kumwa mankhwalawa ndi mowa kumalumikizidwa ndi zizindikilo monga kupweteka kwa mtima, kupweteka mutu, kuthamanga, kukomoka, mutu wopepuka, komanso chizungulire. Kumbali inayi, Stendra ndiotetezeka kugwiritsa ntchito, ngakhale atamwa mowa. Mutha kusangalala ndi magawo atatu a mowa musanatenge Stendra, ndipo sipadzakhala zovuta zina kapena zovuta zina pa thanzi lanu.

Komabe, izi sizitanthauza kuti mutha kumangodya pang'ono ndikugwiritsa ntchito Stendra. Muyenera kumwa mowa pang'ono chifukwa mowa umayambitsanso mavuto ena azaumoyo. Mowa ndiwotopetsa, ndipo mukaugwiritsa ntchito mopitirira muyeso, umachepetsa chikhumbo chanu chogonana ndikupangitsani kuti mukhale ovuta. Zikutanthauza kuti mowa umanyalanyaza zomwe mankhwala a ED amayesetsa kukwaniritsa.

Monga tikuonera, avanafil ili ndi maubwino angapo tadalafil. Ndicho chifukwa chake madokotala ambiri amakonda kupereka kwa odwala awo.

 

Zomwe Mankhwala Ena Amafuna Zimakhudza Avanafil?

Ngakhale mankhwala ena sangathe kugwiritsidwa ntchito limodzi, ena amatha kuphatikizidwa kuti athandize kuchita bwino. Mankhwala omwe sangaphatikizidwe ndi omwe amalumikizana ndipo amayambitsa zovuta. Ndicho chifukwa chake musanamwe mankhwala aliwonse, dziwitsani ngati muli kale ndi mankhwala ena. Izi ziyenera kukhalanso choncho ngati mukufuna kusintha mankhwala osokoneza bongo kapena mlingo. Osamachita chilichonse panokha osaphatikizira omwe amakuthandizani pa zaumoyo.

Mwachitsanzo, mumalangizidwa kuti musagwiritse ntchito avanafil kuphatikiza mankhwala monga Levitra, Staxyn (vardenafil), tadalafil (Cialis), kapena Viagra (sildenafil). Mankhwalawa amagwiritsidwanso ntchito pochiza ED komanso kuthamanga kwa magazi (pulmonary). Chifukwa chake kuzigwiritsa ntchito limodzi ndi avanafil kumatha kulemetsa thupi lanu ndikupangitsa zovuta zina.

Musanayambe kugwiritsa ntchito avanafil, dziwitsani omwe akukuthandizani zaumoyo ngati mukumwa mankhwala aliwonse, makamaka:

• Mankhwala omwe amagwiritsidwa ntchito pochiza kuwonongeka kwa erectile.
• Maantibayotiki aliwonse monga telithromycin, erythromycin, clarithromycin, ndi ena
• Mankhwala onse antifungal, pakati pawo ketoconazole, itraconazole, ndi ena
• Mankhwala aliwonse omwe amagwiritsidwa ntchito pochiza matenda a prostate kapena kuthamanga kwa magazi, kuphatikiza tamsulosin, terazosin, silodosin, prazosin, doxazosin, alfuzosin, ndi ena.
• Mankhwala a hepatitis C monga telaprevir ndi boceprevir ndi ena.
• Mankhwala a HIV / AIDS monga saquinavir, ritonavir, indinavir, atazanavir, ndi ena.

 

Mndandanda uli pamwambapa suli wokwanira. Palinso mankhwala ena monga Doxazosin ndi Tamsulosin omwe akagwiritsidwa ntchito limodzi ndi avanafil amabweretsa mavuto oyipa. Kuphatikiza apo, mankhwala ena ambiri omwe amagulitsidwa pamankhwala ndi mankhwala amatha kulumikizana ndi avanafil. Izi zimaphatikizapo zitsamba ndi mavitamini. Chofunika ndikuti musagwiritse ntchito mankhwala aliwonse kuphatikiza ndi avanafil popanda kudziwa kwa dokotala wanu.

Sikuti ndi mankhwala okha omwe muyenera kusamala nawo, komanso muyenera kukhala osamala mukakhala ndi zovuta zina zamankhwala. Chifukwa chake musanagwiritse ntchito avanafil, dziwitsani dokotala ngati muli ndi zovuta zamankhwala zotsatirazi.

• Mbolo yachilendo - ngati muli ndi mbolo yokhota kapena mbolo yanu ili ndi zolemala zina, pali mwayi waukulu kuti thanzi lanu lingakhudzidwe mukamagwiritsa ntchito avanafil.
• Ngati muli ndi zaka 50 kapena kupitilira apo
• Ngati mukuvutika ndi diski yodzaza ndi anthu, matenda a mtsempha wamagazi, kapena maso anu ali ndi kuchuluka kwa kapu to disc, ndipo ngati mukudwala matenda a mtima kapena shuga, kuchuluka kwamafuta ambiri m'magazi (Hyperlipidemia) kapena magazi ambiri kuthamanga (matenda oopsa).

 

Zina zomwe muyenera kudziwitsa dokotala ndi izi:

• Mavuto akulu amaso
• Kupweteka kwambiri pachifuwa (angina)
• Kugunda kwamtima kosafunikira (arrhythmia)
• Mavuto ndi mitsempha yamagazi monga idiopathic subaortic stenosis kapena aortic stenosis
• Matenda amtima adachitika m'miyezi isanu ndi umodzi yapitayi.
• Kusokonezeka mtima kwa mtima
• Mbiri yakusuta
• Kuthamanga kwa magazi (hypotension)
• Matenda a retinal
• Retinitis pigmentosa
• Sitiroko mkati mwa miyezi isanu ndi umodzi yapitayo
• Kusuta kwa matenda
• Zilonda za m'mimba
• Khansa yokhudzana ndi magazi (leukemia kapena multipleeloma)
• Kuchepa kwa magazi m'matenda, pakati pa ena

PDE5 inhibitors, Stendra kuphatikiza, amalumikizana ndi ma CYP3A4 inhibitors ndi alpha-blockers. Pachifukwa ichi, ndikofunikira kuti dokotala adziwe ngati mukugwiritsa ntchito mankhwalawa. Ponseponse, avanafil ndichothandiza komanso chotetezeka kuchipatala cha ED.

 

Avanafil Phindu

Avanafil imagwiritsidwa ntchito kwambiri pochiza kukanika kwa erectile. Maubwino ena avanafil akuphatikiza kuti imagwira ntchito mwachangu kuposa mankhwala ena onse omwe amagwiritsidwa ntchito pochizira ED. Mutha kutenga mphindi khumi ndi zisanu musanagonane ndipo zithandizabe.

Ubwino wina wa avanafil ndikuti simuyenera kuzitenga tsiku lililonse kuti mukhale ogwira mtima, mutha kuzitenga momwemo komanso nthawi yomwe mukufuna. Avanafil imaloledwa bwino ndi thupi ndipo imatha kumwedwa kapena wopanda chakudya. Avanafil alibe zovuta zambiri monga mankhwala ena a ED, ndipo mutha kumwanso mukamwa mowa.

Chithandizo cha ED ndi chimodzi mwazinthu za avanafil amagwiritsa. Chogulitsachi chimagwiritsidwanso ntchito pochizira chodabwitsa cha Raynaud, vuto lomwe limapangitsa kuti gawo lina la thupi lizizizira komanso kuzizira. Zodabwitsazi za Raynaud zimachitika pakachepetsa magazi kutuluka m'mbali ya thupi, monga mphuno, mawondo, nsonga zamabele, zala zakumapazi, ndi makutu. Vutoli limayambitsanso kusintha kwa khungu.

 

Momwe Mungapindulire Zambiri Kuchokera ku Avanafil 

Avanafil ikuthandizani kuti mukhale ndi erection, koma sizitanthauza kuti mutha kuthana ndi ziwonetserozo. Chifukwa chake musanagonane, yambitsani wokondedwa wanu kuti aziwonetsetse momwe mungachitire popanda kumwa mankhwala. Kumbukirani kuti avanafil ingokuthandizani kuti mukhale ndi erection mukadzutsidwa.

Musamwe mowa wambiri musanagwiritse ntchito avanafil. Kumwa mowa kwambiri kumatha kukulepheretsani kusangalala ndi zotsatira za avanafil kwathunthu. Kuphatikiza mowa ndi avanafil kumatha kuyambitsa zovuta zina monga chizungulire zomwe zingachepetse kugonana kwanu komanso magwiridwe antchito.

Pewani kumwa madzi amphesa mkati mwa maola 24 kuti mukonzekere kutenga avanafil ndikugonana. Madzi a mphesa ali ndi mankhwala ena omwe angapangitse kuchuluka kwa avanafil m'magazi anu motero kukulitsa mwayi wokumana ndi zovuta zina.

Lemekezani nthawi yomwe mwapatsidwa ndi wothandizira zaumoyo kuti athe kuwunika momwe mukuyendera. Ngati mukulephera kupeza erection ngakhale mutatenga avanafil ndikuchita nawo ziwonetsero, kapena ngati mungapeze erection, koma sizikhala motalika kokwanira kuti mugonane ndikufika pachimake, muyenera kudziwitsa dokotala wanu.

Zomwezo zimagwiranso ntchito ngati avanafil akuwoneka kuti ndi wamphamvu kwambiri kwa inu; pamene kumangika kwanu sikuwoneka ngati kumatha mukamaliza kugonana. Adziwitseni dokotala za izi kuti athe kuchepetsa mlingo wanu. Komanso, kumbukirani kuti musatenge avanafil ochulukirapo kuposa zomwe dokotala akukuuzani.

 

Kugwiritsa ntchito Avanafil (Stendra)

Kuti avanafil ikhale yothandiza, zingakuthandizeni ngati mungazitenge monga adanenera dokotala. Adotolo angakuuzeni kuchuluka kwa zomwe mungatenge komanso nthawi yanji.

Monga mankhwala ena osokoneza bongo, avanafil ndiyosavuta kugwiritsa ntchito. Mankhwalawa amabwera mu ufa kapena piritsi. Popeza avanafil amachita mwachangu, muyenera kutenga pakati pa 15 - 30 mphindi musanagonane. Ngati dokotala akukulemberani mlingo wochepa wa avanafil, nenani 50mg patsiku, tikulimbikitsidwa kuti musamwe mankhwala osakwana mphindi 30 musanagonane. Ndiyo njira yabwino kwambiri yowonetsetsa kuti thupi lanu limamwa mankhwala. Ndikoyenera kudziwa kuti mutha kutenga ufa wa avanafil mukakhala ndi njala sizingakhale ndi vuto lililonse pathupi lanu.

Ndikofunika kuti mutenge mankhwalawa kamodzi patsiku. Wothandizira zaumoyo wanu adzawunika momwe thupi lanu limayankhira mankhwalawo ndipo amatha kusintha mlingo kuti mupeze phindu lonse la avanafil.

Pokhala mankhwala akuchipatala, muyenera kulankhula ndi dokotala wanu kuti akupatseni mankhwala kale avanafil kugula. Dokotala adzakufunsani mafunso angapo ndipo ngati kuli kotheka, yesani mayeso kuti muthandize kudziwa kuchuluka kwa mlingo wa avanafil woyenera inu kutengera mtundu wanu wonse umoyo, zaka, ndi mankhwala ena omwe mungagwiritse ntchito. Gwiritsitsani ntchito avanafil malinga ndi zomwe zalembedwazo kapena monga dokotala wanu akuwonetsera. Kumbukirani kuti avanafil sachiza matenda ena kupatulapo zochitika za ED ndi Raynaud.

Avanafil imapezeka mwamphamvu zitatu: 50, 100, ndi 200mg. Ndizotheka kuti dokotala wanu angakuyambitseni pa mphamvu ya 100mg, koma atha kusintha mulingo malinga ndi momwe thupi lanu limayankhira. Nthawi iliyonse mukamagula avanafil powder, onetsetsani chizindikirocho kuti muwonetsetse kuti muli ndi mphamvu yoyenera yomwe mudakonzedwera.

 

CHENJEZO

Kuwunika kwa ED kuyenera kuphatikiza kuwunika kwathunthu kwachipatala kuti muwone ngati pali zoyambitsa, komanso kudziwa njira zina zamankhwala. Mwachitsanzo, kuphatikiza kwamaganizidwe ndi thupi kumatha kuyambitsa ED.

Zinthu zina zathupi zimachedwetsa kuyankha zogonana zomwe zimabweretsa nkhawa zomwe zingakhudze magonedwe. Izi zikathandizidwa, chilakolako chogonana chitha kubwezeretsedwanso. Zomwe zimayambitsa ED ndizo:

• Atherosclerosis (mitsempha yotsekedwa yamagazi)
• Matenda a mtima
• Kuthamanga kwa magazi
• Cholesterol Chokwera
• kunenepa
• shuga
• Matenda a kagayidwe kachakudya - Izi ndizomwe zimachulukitsa kuthamanga kwa magazi, kuchuluka kwa insulin, cholesterol, ndi mafuta amthupi.
• angapo sclerosis
• matenda Parkinson
• Kugwiritsa ntchito fodya

 

• Matenda a Peyronie - ngati minofu yotupa imayamba kutuluka mbolo
• Kumwa mowa mwauchidakwa komanso kugwiritsa ntchito mankhwala osokoneza bongo
• Matenda ogona
• Kuvulala kapena maopaleshoni mumtsempha kapena m'chiuno
• Mankhwala ochiritsira prostate kapena khansa ya prostate
• Testosterone wotsika

 

Ubongo umagwira gawo lalikulu pakudzutsa chilakolako chogonana. Zinthu zingapo zomwe zimakhudza chilimbikitso chogonana zimayamba kuchokera muubongo. Zomwe zimayambitsa matenda a ED ndi izi:

• Kuda nkhawa, kukhumudwa, kapena zochitika zina zomwe zimakhudza malingaliro umoyo
• kupanikizika
• Mavuto abwenzi omwe amabwera chifukwa cholumikizana molakwika, kupsinjika, kapena zovuta zina
• Moyo wosakhutiritsa wogonana
• kunyalanyaza kapena manyazi kapena
• Kulephera kupatsa pakati mnzanu

Wothandizira zaumoyo wanu asanakulamulireni avanafil, sadzangoyang'ana nkhani zili pamwambazi, komanso zotsatirazi:

 

Mavuto amtima

Ngati muli ndi vuto la mtima, mutha kukhala pachiwopsezo cha mtima mukamagonana. Pachifukwa ichi, chithandizo cha erectile chosagwira ntchito pogwiritsa ntchito avanafil sichikulimbikitsidwa kwa iwo omwe ali ndi vuto la mtima.

Odwala omwe ma ventricle akumanzere amalephera kapena omwe ali ndi vuto lodziyimira pawokha pamagazi amatha kutengeka ndi Stendra ndi ma vasodilator ena.

 

Erection yayitali

Ogwiritsa ntchito ena a PDE5 afotokoza za erection yomwe imatenga maola opitilira anayi. Ena afotokozanso zovuta zopweteka zomwe zimatenga maola opitilira asanu ndi limodzi (priapism). Ngati mukukumana ndi izi, muyenera kupita kuchipatala mwachangu. Izi ndichifukwa choti minofu yanu ya penile imatha kuwonongeka mukachedwetsa ndipo mutha kutaya mphamvu zanu mpaka kalekale.

Odwala omwe ali ndi vuto la penile anatomical deform (Peyronie's disease, angulation, or angulation) ayenera kugwiritsa ntchito avanafil mosamala kwambiri. Momwemonso, odwala omwe ali ndi mikhalidwe yomwe ingayambitse kusasamala ayeneranso kusamala pakagwiritsa ntchito avanafil.

 

Kutha maso

Ngati mukusowa masomphenya mukamagwiritsa ntchito Stendra kapena zoletsa zina za PDE5, muyenera kudziwitsa dokotala mwachangu kuti mudzalandire chithandizo choyenera.

Kutaya masomphenya kungakhale chizindikiro cha NAION, zomwe zimachitika mwa anthu ena omwe amagwiritsa ntchito PDE5 inhibitors. Kuchokera kwa ambiri ndemanga za avanafil, mudzazindikira kuti izi sizimachitika kawirikawiri, koma muyenera kuzidziwa.

 

Kumva kutayika

Ichi ndi chikhalidwe china chosowa chokhudzana ndi PDE5 inhibitors. Ngati mukugwiritsa ntchito avanafil ndipo mukumva mwadzidzidzi kapena kuchepa kwakumva, dziwitsani dokotala posachedwa. Kutaya kwakumva nthawi zambiri kumatsagana ndi chizungulire kapena tinnitus, koma sizodziwikiratu kuti zizindikirazi ziyenera kuti zimachokera ku PDE5 inhibitors.

Zili kwa madotolo kuti adziwe chomwe chimayambitsa izi, koma ngati mungazipeze, zingakuthandizeni ngati mutasiya kumwa avanafil mpaka mutapezeka ndi dokotala.

 

Zotsatira za Avanafil

Stendra ndi a otetezedwa, mankhwala othandiza omwe amangokhala ndi zovuta zochepa, ndipo palibe omwe amapezeka. Mwachitsanzo, kupweteka kwa mutu, komwe kumafala kwambiri kwa Stendra, kumangokhudza amuna asanu mpaka 10% omwe amagwiritsa ntchito mankhwalawa.

Chotsatira china chofala cha avanafil chikuuluka. Kuchokera pakuwunika kwa avanafil, zapezeka kuti vutoli limachitika pakati pa 3 - 4% ya ogwiritsa ntchito. Kupweteka kwa mutu ndi kutsuka kumachokera ku zotsatira za avanafil pakuyenda kwa magazi ndipo zotsatirazi nthawi zambiri zimatha patatha maola angapo. Zotsatira zina zoyipa za avanafil zimaphatikizapo kuchulukana kwa mphuno, zizindikilo zozizira (nasopharyngitis), ndi kupweteka kwa msana. Zotsatira zonsezi za avanafil zimachitika mwa ochepa ogwiritsa ntchito.

 

Kumene Mungagule Avanafil

Mukufuna ku Gulani avanafil? Ngati ndi choncho, muyenera kusankha wogulitsa avanafil yemwe angakutsimikizireni kuti ufa wa avanafil womwe mukugula ndi wabwino kwambiri. Ndife ogulitsa. Timapanga zinthu zathu kuchokera ku CMOAPI, wopanga wotchuka wa avanafil.

CMOAPI imapanga osati avanafil komanso mankhwala ena osokoneza bongo. Osadandaula za mtengo wa avanafil. Tikufuna kulumikizana nanu kuti tikupatseni avanafil kwazaka zambiri. Ndicho chifukwa chake mtengo wathu wa avanafil ndiwothandiza kwambiri mthumba.

 

Zothandizira

1. "FDA ivomereza Stendra ya kulephera kwa erectile" (Press release). Chakudya ndi Mankhwala Osokoneza Bongo (FDA). Epulo 27, 2012.
2. "Spedra (avanafil)". European Medicines Agency. Kubwezeretsedwa 17 April 2014.
3. US 6797709, Yamada K, Matsuki K, Omori K Kikkawa K, "zonunkhira zonunkhira zokhala ndi 6-membered cyclic compounds", woperekedwa 11 Disembala 2003, wopatsidwa Tanabe Seiyaku Co
4. "VIVUS Yalengeza Kugwirizana kwa Avanafil Ndi Menarini". Vivus Inc. Yasungidwa kuyambira pachiyambi pa 2015-12-08.
5.  "VIVUS ndi Metuchen Pharmaceuticals Alengeza Pangano la License la Ufulu Wamalonda ku STENDRA". Vivus Inc. 3 Okutobala 2016.
6. 2021 Maupangiri Ogwiritsa Ntchito Mankhwala Osokoneza Ubwino Ogonana Ochiza Erectile Dysfunction (ED).

 

Zolemba Zosintha