Mankhwala a Cannabidiol (CBD)

Cannabidiol (CBDufa Mfundo Zachidule

dzina	Mankhwala a cannabidiol （CBD
Maonekedwe	Woyera mpaka kuwala ufa wachikasu wa crystalline
Cas	13956-29-1
Assay	Zosintha ≥99% (HPLC)
Kutupa	Kusungunuka kwamafuta, kusungunuka kwambiri mu ethanol ndi methanol, osasungunuka m'madzi
Kulemera kwa maselo	314.46
Melt Point	62-63 ° C
Molecular Formula	C21H30O2
gwero	Industrial hemp
yosungirako aganyu	Kutentha kwapakati, khalani owuma komanso opanda kuwala
kalasi	Maphunziro a Zamankhwala

 

Kodi Cannabidiol (CBD)?

Cannabidiol amadziwika kuti CBD yomwe ndi imodzi mwazinthu zopitilira 100 zomwe zimadziwika kuti cannabinoids zomwe zimapezeka mu chamba cha chamba kapena chamba, Cannabis sativa. Imakhala yokhayokha komanso yoyeretsedwa kuchokera ku zitsamba za Cannabis sativa, imangokhala ndi zochepa kwambiri THC. Tetrahydrocannabinol (THC) ndi cannabidiol (CBD) onse amalumikizana ndi ma cannabinoid zolandilira mthupi lonse.Poyerekeza ndi 9-THC, CBD siyopanda poizoni chifukwa sichimapereka zochitika zama psychoactive. Ili ndi zochita za analgesic, anti-inflammatory, antineoplastic and chemopreventive. Pakayendetsedwe ka ntchito, cannabidiol (CBD) imagwiritsa ntchito njira zotsutsana ndi kufalikira, zotsutsana ndi angiogenic ndi pro-apoptotic kudzera munjira zosiyanasiyana, zomwe mwina sizikuphatikiza kuzindikiritsa kwa cannabinoid receptor 1 (CB1), CB2, kapena vanilloid receptor 1. CBD imalimbikitsa endoplasmic kupsinjika kwa reticulum (ER) ndikuletsa kuwonetsa kwa AKT / mTOR, potero kumapangitsa kuyimitsa thupi ndikulimbikitsa apoptosis. Kuphatikiza apo, CBD imakulitsa kupangika kwa mitundu yama oxygen (ROS), yomwe imalimbikitsanso apoptosis. Wothandiziranso amatulutsa mawonekedwe a intercellular adhesion molekyulu 1 (ICAM-1) ndi minofu inhibitor yamatrix metalloproteinases-1 (TIMP1) ndikuchepetsa kufotokozera kwa inhibitor ya DNA yomanga 1 (ID-1). Izi zimalepheretsa kuwonongeka kwa khansa ndi metastasis. CBD itha kuyambitsanso mtundu wa vanilloid mtundu wachiwiri (TRPV2), womwe ungapangitse kuchuluka kwa ma cytotoxic othandizira m'matenda a khansa. Mphamvu ya analgesic ya CBD imayimira pakumangiriza kwa wothandizirayu ndi kuyambitsa kwa CB2. Cannabidiol imagwiritsidwa ntchito kwambiri pamagulu okomoka (khunyu) kapena matenda a dravet komanso kupumula kwamankhwala kwamankhwala opweteka kwambiri am'mimba kapena zowawa zina, monga khansa. FDA idavomereza CBD mu 1, ndipo ndi chithandizo chokhacho chovomerezeka ndi FDA kwa odwala omwe ali ndi matenda a Lennox-Gastaut ndi Dravet.

 

Ckutulutsa (CBD) Njira yogwira ntchito

Njira zenizeni zogwirira ntchito za CBD ndi THC sizikumveka bwino pakadali pano. Komabe, zimadziwika kuti CBD imagwira ntchito cannabinoid (CB) zolandilira za endocannabinoid system, yomwe imapezeka m'malo ambiri mthupi, kuphatikiza zotumphukira komanso machitidwe apakati amanjenje, kuphatikiza ubongo. Dongosolo la endocannabinoid limayang'anira mayankho ambiri amthupi kuphatikiza kupweteka, kukumbukira, njala, komanso malingaliro. Makamaka, ma CB1 receptors amatha kupezeka mkati mwa njira zopweteka zaubongo ndi msana momwe zingakhudzire ma analgesia omwe amayambitsa CBD ndi anxiolysis, ndipo zolandilira za CB2 zimakhudza ma cell amthupi, momwe angakhudzire njira zotsutsana ndi zotupa za CBD. . Cannabidiol (CBD) ndi kagayidwe kamene kamapezeka m'chiwindi ndi m'matumbo. Kusuta bioavailability pafupifupi 31%. Hafu ya moyo wa CBD pambuyo pothira mafuta opopera imakhala pakati pa maola 1.4 ndi 10.9, masiku 2 ndi 5 mutamwa kwambiri pakamwa, ndi maola 31 mutasuta. CBD ikwaniritsa kuchuluka kwa plasma pakati pa 0 ndi 4 hrs. CBD yawonetsedwa kuti imakhala ngati yoyeserera yoyipa ya cannabinoid CB1 receptor, wochuluka kwambiri wa G-Protein Coupled Receptor (GPCR) mthupi. Malamulo a Allosteric of a receptor amakwaniritsidwa chifukwa cha kusintha kwa zochitika za wolandila pamalo osiyana ndi agonist kapena antagonist binding site. Zotsatira zoyipa zoyipa za CBD ndizofunikira kuchiritsa popeza ma agonist owongoleredwa amachepa chifukwa chazovuta zawo pomwe otsutsana nawo amakhala ochepa chifukwa cha zovuta zawo.

 

Momwe Mungagwiritsire Ntchito Ckutulutsa (CBD)?

Cannabidiol (CBD) ndichotenga chamba chomwe chimapangidwa chifukwa chazithandizo zake. Njira ziwiri zomwe zimagulitsira pamsika ndizoyamwa komanso zam'mutu, monga makapisozi, zonunkhira, mafuta, ndi zina zambiri. Kumeza madontho angapo a mafuta a CBD ndi njira yosavuta kwambiri komanso yosavuta yogwiritsira ntchito molekyulu mwanjira imeneyi. Cannabidiol ndi POSSIBLY SAFE ikamwedwa pakamwa kapena kupopera pansi pa lilime moyenerera. Cannabidiol muyezo wa 300 mg tsiku lililonse amatengedwa pakamwa mosamala kwa miyezi isanu ndi umodzi. Mlingo wapamwamba wa 6-1200 mg tsiku lililonse watengedwa pakamwa mosamala kwa milungu inayi. Mankhwala a cannabidiol product (Epidiolex) amaloledwa kumwa pakamwa mpaka 1500 mg / kg tsiku lililonse. Mankhwala a Cannabidiol omwe amagwiritsidwa ntchito pansi pa lilime agwiritsidwa ntchito muyezo wa 4 mg kwa milungu iwiri. Wina amathanso kuwonjezera mafuta a CBD pachakudya ndi zakumwa kuti abise kukoma. Koma kwa iwo omwe akuyang'ana kuti athandizire ndi bondo lopindika kapena kumbuyo kolimba, kirimu atha kusankhidwa.

 

Cannabidiol (CBD) Pindulani

Cannabidiol (CBD mwachidule) ndichinthu chachilengedwe chomwe chimapezeka kuchokera ku chomera cha cannabis. Ndi amodzi mwa zana opitilira cannabinoids omwe amapezeka muzomera za hemp. Komabe, mosiyana ndi chomera chathunthu cha cannabis, CBD ilibe THC yomwe imayambitsa miyala / malingaliro akulu omwe mankhwala osangalatsa amapereka. Kuchokera ku maluwa ndi masamba a chomera cha hemp, CBD imakanikizidwa mu mafuta ndipo imakhala yotchuka kwambiri pochiza, komanso kupewa, mavuto osiyanasiyana azaumoyo kumayiko komwe chamba chamankhwala chaloledwa kale. Mafuta a CBD ndiolimba komanso achilengedwe kuposa mankhwala ambiri osagwiritsa ntchito zotupa (NSAIDs). Zinthu ziwirizi zimatha kutulutsidwa ndikulimbikitsidwa kuti zizigwiritsidwa ntchito kudzera pa distillation yayifupi. Ogwiritsa ntchito atha kupeza izi:

* Kusagona komanso kuda nkhawa

* Matenda a Neurodegenerative

Sungani kugwidwa

Matenda azaumoyo & Matenda okhudzana ndi Khalidwe

* Kugona Kwabwino

* Kusamalira Mavuto

* Thanzi Labwino

* Kuledzera & Kudalira

* Kukula pang'onopang'ono kwa matenda a Alzheimer's

* Amachiza matenda am'matumbo

* .Athandizo amapereka mpumulo kwa anthu omwe ali ndi multiple sclerosis

 

Cannabidiol (CBD) Zotsatira zoyipa

Zotsatira zoyipa za Cannabidiol (CBD) zimaphatikizapo kugona, matenda am'mimba, mkamwa wouma, kuchepa kwa njala, nseru, komanso kuyanjana ndi mankhwala ena.

Cannabidiol (CBDKugwiritsa ntchito

Cannabidiol imagwiritsidwa ntchito kwambiri pamavuto okomoka (khunyu), Cannabinoid amapangidwanso ndi cytochrome P450 enzyme system ndipo amaletsa makamaka michere ya CYP3A4 ndi CYP2D6. THC ndi CBD apezeka kuti amaletsa michere ya CYP1A1, 1A2 ndi 1B1 panthawi ya maphunziro a vitro. Kuphatikiza apo CBD ndiyamphamvu kwambiri yoteteza CYP2C1P ndi CYP3A4. Pomwe mayesero ambiri azachipatala akuchitika, CBD ikuwonetsa kuthekera kochititsa chidwi kokhala mankhwala owonjezera pamaubongo osiyanasiyana. Zapezeka kuti zili ndi antioxidative, anti-inflammatory, and neuroprotective effects. Yawonetsa lonjezo pochiza matenda amitsempha monga nkhawa, kupweteka kosalekeza, trigeminal neuralgia, matenda a Crohn, matenda a Parkinson komanso matenda amisala.

Cannabidiol Chidule

Cannabidiol ndi mankhwala omwe amapezeka pakamwa omwe amagwiritsidwa ntchito pochiza odwala omwe ali ndi khunyu chifukwa cha Lennox-Gastaut kapena Dravet syndrome. Cannabidiol imagwirizanitsidwa ndi kukwera kwa ma enzyme a seramu panthawi yamankhwala makamaka ndimankhwala apamwamba koma sikunalumikizidwe ndi milandu yovulala kwa chiwindi ndi jaundice.

 

Reference

1. Britch SC, Babalonis S, Walsh SL.Cannabidiol: zamankhwala ndi zochiritsira. Psychopharmacology (Berl). 2021 Jan; 238 (1): 9-28. onetsani: 10.1007 / s00213-020-05712-8. PMID: 33221931. (Adasankhidwa)

2. Samanta D. Cannabidiol: Kuwunikanso kwa Kuchita bwino ndi Chitetezo mu Khunyu. Pediatr Neurol. 2019 Jul; 96: 24-29. onetsani: 10.1016 / j.pediatrneurol. PMID: 31053391. (Adasankhidwa)

3. Huestis MA, Solimini R, Pichini S, Pacifici R, Carlier J, Busardò FP.Cannabidiol Zotsatira Zoyipa ndi Chowopsa. Kutulutsa Neuropharmacol. 2019; 17 (10): 974-989 (Pamasamba) onetsani: 10.2174 / 1570159X17666190603171901. PMID: 31161980.

4. Pisanti S, Malfitano AM etc Cannabidiol: Chitukuko cha zaluso ndi zovuta zatsopano pakugwiritsa ntchito mankhwala. Chithandizo. 2017 Jul; 175: 133-150. (Adasankhidwa) onetsani: 10.1016 / j.pharmthera.PMID: 28232276.

5. Burstein S. Cannabidiol (CBD) ndi mafananidwe ake: kuwunikira zomwe zakhudza kutupa. Bioorg Med Chem. 2015 Apr 1; ​​23 (7): 1377-85. onetsani: 10.1016 / j.bmc.2015.01.059. PMID: 25703248. (Adasankhidwa)

 

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