Orlistat

Chidziwitso cha Base cha Orlistat

dzina	Orlistat ufa
Zofuna	White crystalline powder
Cas	96829-58-2
Assay	≥99%
Kutupa	nsoluble m'madzi kapena mowa, sungunuka mu Acetic acid, ethyl ester.
Kulemera kwa maselo	495.7 g / mol
Melt Point	50 ° C
Molecular Formula	C9H7ClN2O5
Mlingo	30mg
yosungirako aganyu	2-8 ° C Pazizira
kalasi	Maphunziro a Zamankhwala

 

Kodi orlistat ndi iti?

Orlistat ndi mankhwala akuchipatala omwe amawonetsedwa ngati chithandizo cha kunenepa kwambiri kuphatikiza ndi kalori wochepetsedwa woyang'aniridwa komanso zakudya zamafuta ochepa. Amagulitsidwa ngati mankhwala akuchipatala pansi pa dzina la orlistat Xenical komanso ngati anti-anti-anti-kunenepa kwambiri dzina la Alli.

Orlistat ndi wokhalitsa m'mimba wam'mimba lipase inhibitor yemwe amagwira ntchito makamaka kuti ateteze mafuta. Orlistat ndi mtundu wambiri wa lipstatin, womwe umagwira ntchito mwachilengedwe pancreatic lipase inhibitor. Orlistat ndiyosavuta komanso yosasunthika motero imasankhidwa kuposa kholo lipstatin.

Orlistat imagwira ntchito yopatsa kuchepa pang'ono pakapita nthawi komanso kumachepetsa mafuta owoneka bwino. Amagwiritsidwanso ntchito ndi njira zina zochepetsera zakudya zopanda mafuta komanso masewera olimbitsa thupi. Phindu lake monga njira ina iliyonse yochepetsera thupi siimangochitika koma njira yayitali, yomwe amalangizidwa ndi akatswiri azachipatala.

Popeza imagwira ntchito poletsa kuyamwa kwa mafuta azakudya zomwe zimawapangitsa kuti atulutsidwe osasintha mu ndowe za anthu, pamakhala zochitika zam'mimba zomwe zimachitika chifukwa chogwiritsa ntchito. Zotsatirazi zimatha kukhala zowopsa komanso zoyipa kwambiri ndi kuchuluka kwa mlingo. Kuthetsa kapena kuchepetsa zovuta zoyipa orlistat iyenera kutengedwa limodzi ndi zakudya zopanda mafuta komanso zowonjezera mavitamini. 

 

Kodi Orlistat imagwira ntchito bwanji & Kodi Zimachitikadi?

Orlistat imadziwika ngati kusankha inhibitor pancreatic ndi gastric lipases. Mavitaminiwa (gastric ndi pancreatic lipases) ndiwo amachititsa kuwonongeka kwa triglycerides (mafuta / lipid mthupi) m'matumbo.

Orlistat makamaka imawonetsa zotsatira zake mu kuwala kwa m'mimba komanso m'matumbo ang'onoang'ono. Orlistat imadziwika kuti imamangiriza kumalo otsalira a serine a gastric ndi pancreatic lipases kuti apange mgwirizano wolimba. Izi ma enzyme zimayimitsidwa ndipo sizimapezeka ku hydrolyze mafuta azakudya monga triglycerides kukhala mafuta acids ndi monogylcerides omwe amatha kutengeka mosavuta ndi thupi.

Ntchito zawo zikaletsedwa, ma triglycerides omwe amapezeka pazakudya za anthu samasinthidwa kukhala mafuta acids omwe thupi limatha kuyamwa. Chifukwa chake, ma triglycerides amatulutsidwa osasintha mu ndowe za anthu. Popeza ma triglycerides osasintha samalowa m'thupi, izi zimabweretsa vuto la caloric lomwe limathandizira kuwongolera kunenepa.

Posachedwa, orlistat yapezeka kuti ndi inhibitor ya thioesterase domain of fatty acid synthase (FAS). Enzyme, thioesterase, imalumikizidwa ndi kuchuluka kwa maselo a khansa koma osati kukula kwa maselo abwinobwino.

 

Kodi orlistat imagwira ntchito ngati simukudya mafuta?

Orlistat imagwira ntchito yochepetsa kuchuluka kwamafuta omwe amalowetsedwa mthupi. Chifukwa chake palibe chifukwa choti mutenge orlistat mukamadya popanda mafuta. Mukakhala kuti mukumwa mankhwala a orlistat ndipo mumadya popanda mafuta, mumalangizidwa kuti muchepetse mlingo kuti mupewe zovuta zina.

Komabe, ngati mungadye chakudya chomwe chili ndi mafuta ambiri, mutha kukhala nacho zotsatira zoyipa monga chopondapo mafuta, gasi m'matumbo komanso kuwona mafuta.

 

Orlistat yotsimikizika kuti ichepetse mafuta owoneka bwino?

Inde, orlistat yatsimikiziridwa mwachipatala kuti imachepetsa mafuta owoneka bwino. Alli (orlistat 60 mg) imavomerezedwa ndi Food and Drug Administration (FDA) ngati mankhwala owerengera kuti athetse kunenepa kwambiri.

Maphunziro azachipatala atsimikizira izi orlistat Sikuti zimangothandiza kuti muchepetse thupi komanso zimachepetsa kwambiri mafuta owoneka bwino. Zapezeka kuti zimachepetsa kuzungulira kwa m'chiuno.

Mafuta owoneka ngati mafuta omwe amatchedwanso kuti mafuta achangu ndi mtundu wamafuta owopsa womwe umasungidwa m'mimbamo motero umazungulira ziwalo zofunika kwambiri monga chiwindi, matumbo ndi kapamba. Mafuta ochulukirapo amathandizidwa ndi mavuto ambiri azaumoyo monga mtundu wa 2 shuga, matenda amtima, khansa ina, matenda oopsa, ndi matenda a Alzheimer's.

Pakuchepetsa thupi, mafuta owoneka bwino ndi amodzi mwa mafuta oyamba kutayika. Izi zimakulitsa thanzi lanu pochepetsa mavuto omwe amabwera chifukwa cha matenda ashuga, matenda oopsa, komanso matenda amtima.

Pakafukufuku wophatikiza omwe akutenga nawo gawo 26, orlistat 60 mg (Alli) adayikidwa katatu patsiku kuphatikiza ndi calorie yochepetsedwa, zakudya zamafuta ochepa kwa miyezi itatu. Zotsatira zake zidawonetsa kuti, orlistat imatha kuchepetsa kwambiri kuzungulira kwa m'chiuno komwe kumafanana ndi mafuta owoneka bwino. Adanenanso kuti 3% amachepetsa thupi komanso 5.6% amachepetsa mafuta owoneka bwino.

Pakafukufuku wina, anthu 123 omwe ali ndi kunenepa kwambiri amapatsidwa orlistat katatu tsiku lililonse kwa masabata 24. Adalangizidwanso kuti azidya zakudya zopanda mafuta ambiri. Pambuyo pa mwezi wachisanu ndi chimodzi, ophunzirawo adachepetsa kuchepa kwa thupi kwa 5.96% ndikuchepetsa kwamafuta a visceral a 15.66%.

 

Kodi orlistat imayambitsa kuwonongeka kwa chiwindi?

Orlistat sichinazindikiridwe kuti ndiyo yomwe imayambitsa chiwindi chowopsa m'mayesero onse azachipatala asanakwane. Komabe, zina mwazovuta zovulala pachiwindi cha orlistat zidanenedwa ndi anthu omwe amagwiritsa ntchito orlistat.

Orlistat imatha kuchepetsa ntchito ya enzyme yofunikira yotchedwa carboxylesterase-2. Enzyme, carboxyleserase-2 imagwira gawo lofunikira pothana ndi chiwindi, impso ndi gawo lonse la m'mimba. Mavitaminiwa akakhala oletsedwa amatha kuyambitsa ziweto zofunika kwambiri. 

Chifukwa chake, Food and Drug Administration yatchula kuvulala kwakukulu kwa chiwindi monga nkhawa yokhudza chitetezo cha orlistat. Izi zimachokera pamilandu pafupifupi 13 yakuwonongeka kwa chiwindi pambuyo pa msika pambuyo pa orlistat.

M'maphunziro omwe adachitika, orlistat sinapezeke chifukwa choopsa chowononga chiwindi. Komabe, chiopsezo chomwe chingakhalepo cha orlistat kuvulala kwa chiwindi chomwe chikugwirizana sayenera kunyalanyazidwa. Ndikofunika kuti nthawi zonse muzifunsira kwa dokotala wanu asanakupatseni orlistat kapena mankhwala aliwonse.

 

Mapindu a Orlistat

Phindu lalikulu la orlistat ndikuchepetsa thupi. M'malo mwake, kuchepa kwa orlistat ndiye phindu lalikulu komanso lodziwika lomwe limapangidwa ndikugulitsidwa. Amagwiritsidwa ntchito pochiza kunenepa kwambiri komanso kuthandizira kuchepa thupi.

Ubwino wa orlistat ndi:

 

Kuchiza kunenepa

Kunenepa kwambiri komanso kunenepa kwambiri kumatanthauza mafuta osazolowereka kapena opitilira muyeso omwe amakhala mthupi. Kudzikundikira kumeneku kumakhala pachiwopsezo chachikulu chathanzi. Muyeso wa kunenepa kwambiri ndi kalozera wamagulu amthupi omwe nthawi zambiri amawerengedwa ngati kulemera kwanu mu kilogalamu yogawidwa ndi lalikulu kutalika kwanu mu mita.

Kunenepa kwambiri kumayenderana ndi mavuto azaumoyo monga matenda amtima, matenda ashuga, khansa ina komanso kuthamanga kwa magazi. Mwamwayi, ngakhale kuchepa pang'ono kumatha kuletsa zovuta zokhudzana ndi kunenepa kwambiri.

Mwachilengedwe, anthu onenepa kwambiri komanso onenepa kwambiri amachepetsa thupi powunika zakudya, moyo wopita ndi masewera olimbitsa thupi. Mankhwala osokoneza bongo kapena ochepetsa thupi amapatsidwa kuti azitsatira moyo wathanzi ngati njira ina.

Kuchepetsa thupi, komabe, sikungakwaniritsidwe mwachangu koma nthawi zambiri kumakhala njira yayitali. Ndondomeko yochepetsera thupi nthawi zambiri imakhala ndi chakudya choyenera, masewera olimbitsa thupi, komanso ngati kuli kofunikira mankhwala. Ndondomeko yochepetsera thupi imawonedwa ngati yopambana mukataya 5% kapena kuposa kulemera kwanu musanathe chaka chimodzi. Izi zikutanthauza kuti muyenera kutaya theka la kilogalamu mkati mwa sabata loyamba la chithandizo. Kuchepetsa kuchepa kumeneku kumakuthandizani kuti muchepetse kunenepa kapena kuchepa kwambiri ndikamapitiliza kulemera.

Orlistat yogwiritsidwa ntchito ndi kuchepa kwa kalori komanso zakudya zamafuta ochepa komanso zolimbitsa thupi zimapereka njira yochepetsera thupi. Orlistat, m'mimba lipase inhibitor, imatha kuchepetsa kuchuluka kwamafuta azakudya omwe mumamwa ndi 25%. Orlistat imagwira ntchito poletsa m'mimba ndi kapamba lipases. Awa ndi ma michere omwe amawononga mafuta azakudya (triglycerides) kukhala mawonekedwe oyipa, mafuta acids kapena monocerides.

Ntchito ya michere iyi ikakhala yoletsedwa, thupi silimatha kuyamwa ma calories koma mafuta amachotsedwa mu ndowe. Ichi ndi gawo lofunikira pakuwongolera kunenepa.

Kafukufuku wambiri wazachipatala wachitika ndikuwonetsa kuti orlistat maubwino ochepetsa kunenepa alidi othandiza.

Pakafukufuku omwe adachita nawo 3,305 omwe anali onenepa kwambiri, orlistat idaperekedwa pa 120 mg katatu tsiku lililonse kwa zaka 4. Ophunzirawo adalangizidwanso kuti azidya zakudya zopatsa mphamvu zopatsa mphamvu zopitilira 30% zama calories. Anawalangiza kuti azichita masewera olimbitsa thupi tsiku lililonse.

Kafukufukuyu adapeza kuti, kulemera kwapakati pazaka zoyambirira kunali pafupifupi 10.6 kg. Ngakhale omwe adachita nawo kulemera pazaka zitatu zapitazi zoyeserera, pamapeto pake, omwe anali ochepa thupi anali pafupifupi 5.8 kg.

Mu kafukufuku wina wa chaka chimodzi orlistat yoyendetsedwa idapezeka kuti idapangitsa 5% kapena kutaya kwambiri.

Maubwino ena a orlistat ndi awa;

 

Orlistat Kuchepetsa chiopsezo cha mtundu wachiwiri wa matenda ashuga

Mtundu wachiwiri wa shuga kapena matenda a shuga ndi vuto lalikulu lomwe limakhudza kagayidwe kake ka shuga (glucose) mthupi. Zimachitika pamene matupi athu samazindikira insulini. Insulini ndiye mahomoni omwe amachititsa kuti shuga (glucose) izituluka mthupi. Zitha kuchitika ngati kapamba sichimatulutsa insulini yokwanira kuti isunge ma glucose oyenera mthupi.

Ngakhale zomwe zimayambitsa matenda a insulini sizidziwika bwino, kunenepa kwambiri ndichimodzi mwazinthu zomwe zimathandizira kukulitsa mtundu wa 2 shuga. Mtundu wachiwiri wa matenda ashuga atha kukhala osavuta kunyalanyaza pamene ukukula pang'onopang'ono, komabe, ngati osachiritsidwa atha kubweretsa zovuta zina. Mtundu wapamwamba wa shuga wa 2 umatha kubweretsa zovuta zambiri monga matenda oopsa, matenda amtima komanso matenda amtima. Zizindikirozi zimaphatikizapo kukodza pafupipafupi, kuwonjezeka ludzu, kuonda mwangozi, kutopa, kusawona bwino, matenda opatsirana pafupipafupi, zilonda zochepetsetsa komanso kuda m'malo ena akhungu monga khosi ndi nkhwapa.

Orlistat ndi mankhwala ochepetsa thupi chifukwa chake amatenga gawo lofunikira poletsa kuyambika kwa mtundu wa 2 shuga. Zochita zina za orlistat zomwe zimapezeka mu mtundu wa 2 wa shuga zimaphatikizapo kukulitsa chidwi cha insulin, kuchepetsa mafuta am'magazi osagwiritsidwa ntchito pambuyo pake, kuchepetsa kapena kupewa kuyamwa kwa mafuta azakudya, kuchepetsa mafuta a visceral, komanso kuyambitsa kutsekemera kwa peputide-1 wa glucagon m'matumbo aang'ono m'munsi.

Pakafukufuku ndi anthu onenepa kwambiri, orlistat yomwe imatsagana ndi moyo wathanzi (zakudya zamafuta ochepa komanso masewera olimbitsa thupi) zidapezeka kuti zimachepetsa kwambiri matenda amtundu wa 2. Zinachititsanso kuchepa kwakukulu.

Kafukufuku wina adachitika ndi anthu onenepa kwambiri kapena onenepa kwambiri omwe ali ndi matenda amtundu wa 2. Orlistat 120 mg amayendetsedwa katatu tsiku lililonse kwa miyezi 6 kapena 12.

Zinapezeka kuti kupatula orlistat kulemera kwake, orlistat idatha kukonza kuwongolera kwa glycaemia. Magawo a glycaemia omwe adasintha anali kuchepa kwa glucose wamagazi (FPG) ndi hemoglobin A1c (HbA1c). Kuwongolera koyenera kwa glycaemia kunali kopanda kuchepa thupi.

 

Orlistat  Ikhoza kutsitsa kuthamanga kwa magazi

Kuthamanga kwa magazi komwe kumatchedwanso kuthamanga kwa magazi ndi thanzi lomwe limachitika kuthamanga kwa magazi kwanu kumakwera kwambiri ndipo nthawi zambiri kumakhala kosavomerezeka. Kuthamanga kwa magazi kumawonjezeka mitsempha yake ikafupika.

Kuwonetsedwa kwa nthawi yayitali ndi kuthamanga kwa magazi kumatha kubweretsa zovuta zina zomwe zimakhudza ziwalo zofunika monga mtima, impso maso aliwonse. Zizindikiro zofala kwambiri za matenda oopsa ndimutu, kupweteka magazi, kusintha kwa masomphenya, chizungulire, kupweteka pachifuwa, kupuma pang'ono komanso magazi mkodzo.

Orlistat yomwe ndi lipases inhibitor imathandizira kupewa kuyamwa kwa mafuta azakudya omwe nthawi zambiri amatha kutseka mitsempha. Orlistat imatha kuchepetsa kuthamanga kwa magazi komwe kumachitika chifukwa cha kunenepa kwambiri.

Pakafukufuku wophatikiza anthu 628 onenepa kwambiri kapena onenepa kwambiri omwe ali ndi matenda oopsa, orlistat idaperekedwa pa 120 mg katatu patsiku kwa chaka chimodzi. Odwalawa anali ndi vuto losalamulirika la diastolic lapanikizika. Kuphatikiza pa mankhwala a orlistat, odwala omwe tidawalangiza kuti azisunga zakudya zamafuta ochepa panthawiyi.

Kafukufukuyu adanenanso zakuchepa kwakukulu komanso kuchepa kwa ma diastolic komanso ma systolic hypertension. Adalemba -9.4 mmHg kuchepetsedwa kwa systolic hypertension ndi -7.7 mmHg kuchepetsa kuthamanga kwa diastolic.

Izi zikuwonetsa kuti orlistat itha kugwiritsidwa ntchito pochiza matenda oopsa mwa anthu onenepa kwambiri kapena onenepa kwambiri.

Kuchepetsa pang'ono kwa kuthamanga kwa magazi kumalumikizidwa ndi kugwiritsidwa ntchito kwa orlistat kwakanthawi kochepa komwe kumatsagana ndi chakudya chochepa cha kalori komanso masewera olimbitsa thupi.

Pakafukufuku wina, kugwiritsa ntchito orlistat kwakanthawi kochepa kunapezeka kuti kumachepetsa pang'ono kuthamanga kwa magazi ndikuchepetsa kwa 2.5 mmHg ya systolic pressure ndi 1.9 mmHg ya diastolic magazi. 

 

Orlistat  Amachepetsa cholesterol chonse ndi LDL

Mafuta otsika kwambiri a lipoprotein cholesterol (LDL cholesterol) nthawi zambiri amatchedwa cholesterol woyipa chifukwa amadzipezera m'makoma amitsempha yamagazi motero kukulitsa chiopsezo chanu chazovuta zathanzi monga matenda amtima ndi sitiroko.

Cholesterol chonse chimakhala ndi mafuta otsika kwambiri a lipoprotein (LDL) komanso cholesterol yochulukitsitsa ya lipoprotein (HDL). Kutalika kwa cholesterol yathunthu kumawonjezera chiopsezo chamatenda amtima.

Orlistat akuti amachepetsa cholesterol cha LDL kuphatikiza phindu lakuchepetsa thupi.

Pakafukufuku wophatikizapo odwala onenepa kwambiri kapena onenepa kwambiri, orlistat idaperekedwa pamlingo wa 120 mg katatu tsiku lililonse kwamasabata 24. Odwala anali ndi BMI (index mass body) ya 27-40 kg / m2 ndi hypercholesterolemia (low-density-lipoprotein cholesterol, LDL-C, 4.1-6.7 mol / l).

Orlistat idapezeka kuti imachepetsa kwambiri kulemera komanso cholesterol yathunthu ndi LDL. Zinawonetsedwanso kuti kutsitsa kwa LDL cholesterol kumayimira palokha kupatula kulemera kwake. Pakafukufukuyu orlistat idaloledwa kupatula zochitika zazikulu zam'mimba.

Pakafukufuku wina, anthu 448 omwe ali ndi cholesterol yambiri amapatsidwa orlistat pa 120 mg katatu patsiku pafupifupi miyezi 6. Odwalawo adalangizidwanso kuti azitsatira kalori wocheperako komanso zakudya zamafuta ochepa. Izi zidapangitsa kuti muchepetse kunenepa kwambiri ndikuchepa kwapakati pa 7.4 kg. Mofananamo, panali kuchepa kwakukulu kwa cholesterol yonse ndi lipoprotein cholesterol yochepa ndi 25-30 mg / dL.

Ananenanso kuti kuchepa kwa cholesterol cha orlistat kunali kodziyimira pawokha pa orlistat kulemera kutaya zotsatira.

 

Kuyanjana kwa Orlistat

Kuyanjana kwa mankhwala kumatanthauza momwe mankhwala osiyanasiyana amalumikizirana kapena kukhudzira ena. Kuyanjana kwa mankhwalawa kumathandizira momwe mankhwala ena amagwirira ntchito ndipo kumatha kukulitsa zovuta zoyipa zomwe zimadza chifukwa chogwiritsa ntchito mankhwala ena. Kuyanjana kwa Orlistat ndi mankhwala ena kwadziwika.

Kuwonjezera pa kuyanjana ndi mankhwala ena, orlistat sivomerezedwe kuti agwiritsidwe ntchito ndi amayi apakati kapena oyamwitsa. Siyenera kugwiritsidwanso ntchito ndi ana ochepera zaka 12.

Ndikofunika kwambiri kuti mukhale ndi mndandanda wazamankhwala kapena mankhwala ndikuwululira omwe akukuthandizani zaumoyo kuti akupatseni upangiri wabwino pazomwe mungachite. Kugwirizana kwa mankhwalawa kumatha kukhala kovulaza thanzi lanu mopitilira zabwino zomwe zidatengedwa. Chifukwa chake, musanyalanyaze kuyanjanaku koma m'malo mwake pewani zoteteza.

Zina mwazodziwika bwino za orlistat ndi;

 

Kuyanjana kwa Orlistat ndi ochepetsa magazi

Ochepetsa magazi ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda ena amtima ndi zomwe zimayika pachiwopsezo cha magazi owopsa. Nthawi zambiri amathandizira kuti magazi aziyenda bwino mumitsempha yamagazi. Zimatetezanso kuundana kwa mapangidwe kapena kukula.

Omwe amawonda magaziwa ndi monga warfarin, heparin, apixaban, dabigatran ndi rivaroxaban powder pakati pa ena.

Orlistat imachepetsa kuyamwa kwa vitamini K. Vitamini K ndi gulu lamagulu mwachitsanzo Vitamini k1 ndi vitamini K2. Vitamini K amatenga gawo lofunikira pothandiza magazi kuundana komanso kupewa magazi ambiri. Pamene kuyamwa kwake kuli kochepa, mumakonda kutuluka magazi mosavuta. Ichi ndichifukwa chake kutenga opopera magazi pamodzi ndi orlistat kumawonjezera mwayi wanu wopezeka magazi kwambiri ndipo zimatha kukupangitsani magazi mosavuta.

Zaumoyo wina angakulangizeni kuti musinthe kuchuluka kwanu kwa omwe amapatula magazi kuti athe kuwagwiritsa ntchito limodzi ndi orlistat. Komabe, pokhapokha ngati atavomereza musasinthe miyezo ya mankhwala osokoneza bongo.

 

Kuyanjana kwa Orlistat ndi mankhwala a HIV

Mankhwalawa amatchedwanso mankhwala ochepetsa mphamvu ya kachilombo ka HIV. Mankhwala ochepetsa mphamvu ya kachilombo ka HIV amaperekedwa kwa anthu omwe ali ndi kachilombo ka HIV kamene kamachepetsa chitetezo cha mthupi (HIV) kuti achepetse kuchuluka kwa tizilombo toyambitsa matenda.

Mankhwalawa ndi lopinavir, ritonavir, atazanavir, efavirenz, tenofovir ndi emticitabine.

Mankhwalawa atatengedwa limodzi ndi orlistat, zanenedwa kuti ma antiretroviral virology amachepetsa motero kuchuluka kwa ma virus a HIV kumachulukirachulukira. Muyenera kupewa kugwiritsa ntchito orlistat ndi ma antiretroviral nthawi imodzi.

Ngati pakufunika kuti awatenge limodzi, kuchuluka kwa ma virus a HIV kuyenera kuyang'aniridwa mosamala ndikugwiritsa ntchito orlistat kuyenera kuthetsedwa ngati kuchuluka kwa ma virus kwapezeka.

 

Kuyanjana kwa Orlistat ndi mankhwala ogwidwa

Mankhwala osokoneza bongo amatchedwanso antiepileptic mankhwala omwe amagwiritsidwa ntchito pochepetsa kugwa / matenda akhunyu. Mafuta ndi gawo lofunikira mwa odwala khunyu. Izi zimabweretsa kunenepa monga zotsatira zoyipa za mankhwalawa. Mankhwala osokoneza bongo amaphatikizapo lamotrigine.

Orlistat mbali inayo imachepetsa kuyamwa kwa mafuta. Pogwiritsidwa ntchito limodzi ndi mankhwala a antiepileptic, orlistat akuti amachepetsa kuyamwa kwa mankhwalawa.

Ena anecdotal akuti orlistat yatengedwa pamodzi ndi mankhwala olanda kumawonjezera zochitika za kulanda.

 

Kuyanjana kwa Orlistat ndi cyclosporine

Cyclosporine yomwe imadziwikanso kuti ciclosporin ndi mankhwala ochiritsira omwe amateteza ma immunosuppressant. Amagwiritsidwa ntchito poletsa thupi kukana ziwalo mukatha kuziika.

Pogwiritsidwa ntchito limodzi, orlistat imachepetsa kwambiri kuchuluka kwa plasma ya cyclosporine. Izi ndichifukwa choti orlistat imatha kusokoneza kuyamwa kwa mankhwalawa.

Akatswiri ena azachipatala amalimbikitsa kuti musagwiritse ntchito orlistat mukamagwiritsa ntchito cyclosporine. Komabe, madokotala ena amalimbikitsa kumwa cyclosporine pafupifupi maola 3 mutatenga orlistat.

 

Kuyanjana kwa Orlistat ndi amiodarone

Izi zikutanthauza mankhwala osokoneza bongo omwe amagwiritsanso ntchito kubwezeretsa kugunda kwamtima komanso kukhala ndi mayendedwe okhazikika komanso okhazikika.

Orlistat yasonyezedwa kuti iwononge kuyamwa kwa amiodarone m'magazi. Kuletsa uku kumabweretsa kugunda kwamtima kosafunikira komwe kumawopsa.

 

Kuyanjana kwa Orlistat ndi levothyroxine

Levothyroxine ndi mankhwala omwe amagwiritsidwa ntchito pochiza chithokomiro chotsika komanso amathandizanso mitundu ina ya zotupa. Ntchito zochepa za chithokomiro zimatchedwa hypothyroidism ndipo zimakhudza zizindikilo monga Kutopa, khungu louma, kukumbukira kukumbukira, kunenepa, kutopetsa, kufooka kwa minofu, kuchuluka kwama cholesterol, olemera kuposa kusamba kwanthawi zonse, kugunda kwa mtima, kupsinjika ndi goiters .

Kuphatikizika kwa levothyroxine ndi orlistat akuti kumachepetsa kuchuluka kwa levothyroxine. Orlistat akuti amamangirira levothyroxine motero, kutseka kuyamwa kwake m'matumbo. Izi zitha kubweretsa hypothyroidism yayikulu yomwe ingayambitse mavuto azaumoyo monga kusabereka, kunenepa kwambiri, kupweteka, komanso kusokonezeka kwa mtima. 

 

Kuyanjana kwa Orlistat ndi mavitamini osungunuka mafuta

Orlistat ikhoza kulepheretsa kuyamwa kwa mavitamini osungunuka mafuta komanso zakudya zina. Mavitamini osungunuka amafuta amaphatikiza mavitamini A, D, E, K ndi beta-carotene.

Ndikofunika kuti mutenge mankhwala a multivitamin okhala ndi mavitamini osungunuka. Mankhwala a multivitamin ayenera kumwedwa osachepera maola 2 asanadye orlistat.

 

Zotsatira zoyipa za Orlistat

Zotsatira zofala kwambiri za orlistat zimachitika chifukwa cha mafuta osagwiritsidwa ntchito omwe amadutsa m'mimba mwanu. Amakhala makamaka m'mimba chifukwa njira yoyamba ya orlistat imamveka pakamwa ndipo mafuta osasinthika amatuluka mu ndowe.

Zotsatira zoyipa za orlistat zimachitika m'masabata ochepa atangotenga ndipo zimatha. Komabe, zizindikilo zina zimapitilizabe. Zotsatira zake zoyipa zimatha kuchitika nthawi zambiri ngati mlingowo suli wolondola.

Zotsatirazi zitha kupezedwa mukamamwa mankhwala oyenera mukamatsatira upangiri wa adotolo pokhala ndi kalori wochepa, zakudya zamafuta ochepa komanso masewera olimbitsa thupi.

Mlingo woyenera wa orlistat ndi 120 mg womwe umatengedwa katatu tsiku lililonse. Orlistat iyenera kutengedwa musanadye chifukwa nthawi zambiri imaletsa pafupifupi 30% yamafuta azakudya. Mlingo wapamwamba wa orlistat sizimayambitsa zovuta koma zimatha kubweretsa zovuta zina.

Zotsatira zoyipa za orlistat ndi monga;

• Kuthamanga kapena kuvutika kuwongolera matumbo
• Kutaya matumbo nthawi zambiri
• Mafuta kapena mafuta okhala pansi
• Kupweteka m'mimba kapena kwammbali kapena m'mimba kusapeza bwino
• Kudutsa gasi nthawi zambiri ndikutulutsa mafuta kumatako.

Zotsatira za orlistat pamwambapa zitha kukulirakulira ngati mutenga mafuta ochulukirapo kuposa momwe muyenera kumwa mukamamwa mankhwala a orlistat.

Zovuta zina za orlistat ngakhale sizimachitika kawirikawiri. Mukulangizidwa kuti mupite kuchipatala mwachangu mukawona izi. Zotsatira zoyipa izi zitha kupezeka pamlingo wambiri wa mankhwalawa. Zotsatirapo zake ndi monga;

• litsipa
• nkhawa
• Kulowerera mu msambo
• Kupeza zovuta kupuma
• Zovuta kumeza
• Kupweteka kwambiri m'mimba komwe sikudzatha
• Chizungulire kwambiri
• Kutupa (makamaka lilime, mmero kapena nkhope).

Popeza zochitika zina zosawerengeka zovulala pachiwindi zalumikizidwa ndi kugwiritsa ntchito orlistat, onetsetsani kuti mukuyang'anira zizindikiro zakuvulala kwa chiwindi. Muyenera kuyima nthawi yomweyo ndikupempha chithandizo chamankhwala ngati mukukumana ndi zizindikiro zotsatirazi zovulala pachiwindi;

• Kutopa kwanthawi yaitali
• Kutaya njala
• Ming'oma kapena kuyabwa kwambiri komanso kosalekeza
• Kufooka
• Kusanza kapena kunyansidwa
• Jaundice (chikasu cha maso kapena khungu)
• Mabala owala / owoneka bwino
• Mtsinje wakuda
• Kukulira mosavuta
• Kutupa ndi akakolo kapena miyendo.

Tinalemba zovuta zambiri za orlistat ndipo ngakhale zoyipa zomwe zimakhudzana ndi izi, komabe, khalani ofunitsitsa nthawi zonse kuwona zomwe mungakumane nazo ndikulankhula ndi omwe amakuthandizani. Onetsetsani kuti mwatsatira malangizo mozama pamlingo ndi kagwiritsidwe ntchito koyenera ka orlistat kuti muchepetse zovuta zambiri. 

Mofanana ndi mankhwala ambiri, zotsatirapo zake zimatha kuchitika koyambirira kwa chithandizo ndikutha chifukwa chogwiritsa ntchito komabe, zovuta zina zimapitilira. Kuledzera mopitirira muyeso ndichinthu chinanso chomwe chimapangitsa kuti pakhale zovuta zambiri, chifukwa chake simutenga orlistat yochulukirapo kuposa momwe mukufunira.

 

Ali kuti Gulani Orlistat?

Zida zomwe zili ndi orlistat zimapezeka m'maina osiyanasiyana a orlistat. Izi ndichifukwa choti opanga orlistat amasiyana komanso ndende.

Mlingo wotsika wa orlistat umapezeka m'mazina amtundu wa orlistat monga Alli ndi Orlos. Izi zitha kugulidwa mosavuta pa intaneti kuchokera kwa opanga ambiri orlistat ndi ogulitsa orlistat. Komabe, mukawona orlistat mugule kwa asayansi ovomerezeka. CMOAPI ndi m'modzi mwa opanga orlistat ndipo amapereka zinthu zabwino. Pulogalamu ya CMOAPI kampani yakhala ili mu bizinesi kwanthawi yayitali motero imatsimikizira mtundu wa orlistat wabwino.

Samalani kwambiri ndi mankhwala osokoneza bongo. Werengani zilembozo mosamala kuti mumvetsetse kagwiritsidwe ntchito ka mankhwalawa. Fufuzani wopanga orlistat kapena fayilo ya opereka ma orlistat, tsiku lopanga komanso tsiku lotha ntchito. Onetsetsani kuti muwone zovuta zilizonse zomwe zikuwonetsedwa ndi chenjezo. Mwachitsanzo, kuvulala kwa chiwindi ndi orlistat ndi chimodzi mwa chenjezo kapena m'malo mwa chiwonetsero cha Food and Drug Administration (FDA) kuti ogwiritsa ntchito azisamala akamamwa mankhwala.

 

Zothandizira

1. "Chizindikiro cha US orlistat" (PDF). FDA. Ogasiti 2015. Yotulutsidwa 18 Epulo 2018. Kuti mumve zambiri za lembalo onani tsamba la FDA la NDA 020766
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3. Bodkin J, Humphries E, McLeod M (2003). "Kuphatikiza kwathunthu kwa (-) - tetrahydrolipstatin". Zolemba za Australia za Chemistry. 56 (8): 795-803. onetsani: 10.1071 / CH03121.
4. Filippatos, Theodosios & Derdemezis, Christos & Gazi, Irene & Nakou, Eleni & Mikhailidis, Dimitri & Elisaf, Moses. (2008). Zotsatira Zotsutsana ndi Orlistat ndi Kuyanjana Kwa Mankhwala Osokoneza bongo. Chitetezo cha mankhwala osokoneza bongo: nyuzipepala yapadziko lonse lapansi yokhudza zamankhwala zamankhwala zamankhwala komanso zamankhwala. 31. 53-65. 10.2165 / 00002018-200831010-00005.
5. Sharma, AM, & Golay, A. (2002). Zotsatira za orlistat-zomwe zimapangitsa kuti muchepetse kuthamanga kwa magazi ndi kugunda kwa mtima mwa odwala onenepa omwe ali ndi matenda oopsa Zolemba za matenda oopsa, 20(9), 1873–1878. doi.org/10.1097/00004872-200209000-00034.
6. Wotilimbitsidwa ndi cholembera chaching'ono pa cholembedwacho, ndi bala pamwamba pa i (ndiye kuti, "allī"), koma limaphatikizidwa pamsonkhano.
7. Zhi J, Melia AT, Eggers H, Joly R, Patel IH (1995). "Kuwunikanso kwakanthawi kochepa ka orlistat, lipase inhibitor, mwa anthu odzipereka athanzi". J Clin Pharmacol. 35 (11): 1103-8. onetsani: 10.1002 / j.1552-4604.1995.tb04034.x. PMID 8626884.