Sesamol

Sesamol ufa Mfundo Zachidule

dzina	Sesamol ufa
Zofuna	White powder
Cas	533-31-3
Assay	≥99%
Kutupa	nsoluble m'madzi kapena mowa, sungunuka mu Acetic acid, ethyl ester.
Unyinji wa Molar	138.12 g / mol
Melt Point	62 ku 65 ° C (144 ku 149 ° F; 335 ku 338 K)
Molecular Formula	C7H6O3
Malo otentha	21 mpaka 127 ° C (250 mpaka 261 ° F; 394 mpaka 400 K) pa 5
SMILES	mmHgO1c2ccc (O) cc2OC1

 

Ndi chiyani? Sesamol?

Sesamol ndi chilengedwe cha phenol chomwe chimapezeka mumafuta a sesame osakanizidwa ndi nthangala za sesame. Sesamol (CAS 533-31-3) amawerengedwa kuti ndi gawo lalikulu la mafuta azitsamba omwe amathandizira pakuthandizira.

Sesame (Sesamum chizindikiro) ndi mafuta ofunikira m'mabanja a Pedaliaceae. Amadziwika kuti ndi amodzi mwa mafuta akale kwambiri omwe amadziwika ndi kugwiritsidwa ntchito ndi munthu osati phindu lake lokha komanso mankhwala. Mbali zazikulu za zitsamba zopereka chithandizo ndi masamba ndi mafuta a mbewu.

Gulu la Sesamol 533-31-3 limapezeka mosiyanasiyana kupatula mitundu ina ya lignin yamafuta a sesame, sesamin ndi sesamolin. Malo osungunuka amadzi awa amadziwika kuti ndi antioxidant wamphamvu.

 

Kodi sesamol work?

Sesamol imagwira ntchito m'njira zosiyanasiyana kuti ipereke chithandizo chake chachikulu monga neuroprotection, antioxidant zotsatira, anti-inflammatory, anti-tumor, anti-radiation komanso zowononga kwambiri.

Pansipa pali mitundu ina yomwe sesamol imagwira ntchito kuti akwaniritse zomwe zanenedwa;

 

I. Imaletsa kuwonongeka kwa DNA chifukwa cha kupsinjika kwa oxidative

Sesamol ikhoza kuletsa kuwonongeka kwa DNA chifukwa cha kupsinjika kwa radiation. Kuchepetsa ma radiation kumawononga ma DNA pochepetsa ma chromosomal aberrations ndi micronuclei m'maselo omwe akukula.

 

II. Zimalimbikitsa ntchito ya antioxidants yofunika

Sesamol amagwira ntchito pakuwongolera zochitika za michere yofunika antioxidant monga catalase (CAT), superoxide dismutase (SOD), ndi glutathione peroxidase (GPx), yomwe imatsagana ndi kuchuluka kwa kuchepa kwa glutathione (GSH). Izi ma enzyme amatenga gawo lofunikira popewa kuwonongeka kwama cell ndi zopitilira muyeso.

 

III. Amaletsa mapuloteni otchedwa apoptotic motero amathandizira kuti maselo azigwira ntchito bwino

Mapuloteni a pro-apoptotic ndi mapuloteni omwe amalimbikitsa kufa kwamaselo. Mulinso p53, caspase-3, PARP, ndi michere yoyipa. Mavitaminiwa amaphatikizidwa ndi kufa kwa ma cell chifukwa chake kumatha kuchepetsa mphamvu yama cell.

Sesamol yawonetsedwa kuti imalimbikitsa kuchitapo kanthu kwama cell poletsa zochitika za ma enzyme a pro-apoptotic.

 

IV. Kuletsa kwa lipid peroxidation

Lipid peroxidation ndi mtundu wa kuwonongeka kwa lipid komwe kumachitika chifukwa cha makutidwe ndi okosijeni. Izi zimapangitsa kupanga ma aldehydes othandizira, monga malondialdehyde (MDA) ndi 4-hydroxynonenal (HNE) omwe amawononga maselo. Sesamol yasonyezedwa kuti iteteze lipid peroxidation potero imapereka chitetezo kumaselo.

 

V. Imaletsa kupanga kwamphamvu kopitilira muyeso kuphatikiza ma hydroxyl radicals

Zowonjezera zaulere ndi mankhwala osakhazikika omwe amakhudzana ndi matenda ndi ukalamba. Ma Hydroxyl radicals ndi ma oxidants amphamvu kwambiri omwe amayambitsa matenda.

Sesamol imachepetsa kupangika kwa zinthu zopitilira muyeso kuphatikiza hydroxyl, α, α-diphenyl-β-picrylhydrazyl (DPPH), ndi ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) kwambiri.

 

VI. Zimathandizira ntchito zowononga kwambiri

Kuphatikiza pa kuletsa kupangika kwa zopitilira muyeso, sesamol imatha kuthetseratu zopitilira muyeso monga hydroxyl, lipid peroxyl ndi tryptophanyl radicals.

 

VII. Kupondereza kwa maselo otupa

Sesamol imalepheretsa kuwonetsa njira zomwe zimakhudzidwa ndikupanga mitundu yachilengedwe motero amachepetsa kuyankha kotupa.

 

VIII. Imachepetsa zotupa zotupa (TNFα, IL-1β, ndi IL-6)

Nitric oxide, yopangidwa ndi iNOS, imayambitsa kutupa kwamapapo poyambitsa ma cytokines otupa, monga TNFcy, ndikuthandizira kuyankha kotupa. Sesamol imatha kuletsa kutulutsa kwa TNFcy ndi IL-1β.

 

IX. Kumangidwa kwa kukula kwama cell magawo osiyanasiyana

Sesamol yawonetsedwa kuti imapangitsa kuti kukula kwamaselo kumangidwe magawo osiyanasiyana amakulidwe amitundu kuphatikiza gawo la S ndi G0 / G1. Katundu wa khansa wa Sesamol amathandizira, mwachitsanzo, kuchepetsa kukula kwa maselo a khansa.

 

X. Kukhazikitsa njira yapa caspase

Ma caspases ndi ma enzyme omwe amapezeka pakufa kwamaselo. Sesamol yawonetsedwa kuti imayambitsa njirazi motero zimabweretsa khansa kufa kwama cell.

 

XI. Imapangitsa apoptosis kudzera munjira zamkati komanso zakunja

Apoptosis ndimachitidwe okhudzana ndi thupi momwe kufa kwama cell kumachitika. Ndi njira yofunikira chifukwa imathandizira thupi kuchotsa maselo akufa.

Sesamol imapangitsa apoptosis m'njira ziwiri zosiyana, zamkati komanso zakunja.

 

XII. Zimalepheretsa autophagy ya mitochondrial

Autitogy ya Mitochondrial ndi mtundu wina wakuwonongeka komwe kumathandizira kuthana ndi mitochondria yolakwika.

Sesamol ikaletsa izi, ndiye kuti apoptosis imayambitsidwa.

 

XIII. Amachepetsa kuchuluka kwa nitrite ndi neutrophil

Ma nitititi ndi ma neutrophils amathandizira poyankha kotupa. Amakhudzidwa ndikutulutsa kwa nitric oxide yomwe imayankha kuyankha kotupa pakuchepetsa kapena kuletsa kutupa.

Sesamol amatenga gawo ngati anti-yotupa wothandizira pochepetsa ma nitrites ndi neutrophils.

 

Ndi chiyani? sesamol yogwiritsidwa ntchito?

Sesamol imagwiritsidwa ntchito pazithandizo zosiyanasiyana kuphatikiza;

 

i. Kuthamanga kwa magazi.

Mafuta a Sesame amagwiritsidwa ntchito limodzi ndi mankhwala ochepa a magazi monga mankhwala otsimikiziridwa kuti achepetse kuthamanga kwa magazi.

Kafukufuku wambiri wamafuta a sesame akuwonetsa kuti sesamol ndi sesamin (lignans omwe amapezeka mu sesame mafuta) amatenga gawo lalikulu pakukhazikitsa kuthamanga kwa magazi. Kutenga mafuta a sesame, makamaka kuphika nawo, kwa milungu itatu kumachepetsa kuthamanga kwa magazi kwa anthu omwe ali ndi matenda oopsa kwambiri.

Pakufufuza, akatswiri azachipatala adapereka gulu la odwala matenda oopsa (Procardia, Nefedica ndi Adelta) kwa masiku 21. Ngakhale panali kuchepa pang'ono pamavuto awo amwazi, sizinali zachilendo. Mafuta a Sesame adagwiritsidwa ntchito m'malo mwa mankhwalawo, ndipo odwala adayesedwa nthawi yomweyo. Zotsatira zake zinali zakuti kuthamanga kwa magazi kwawo kudatsika bwino.

Madokotala amati zotsatirazi zidathandizidwa kwambiri ndi kuchuluka kwa sesamol ndi sesamin m'mafuta ophikira a sesame. Ngati zidapezeka kuti kuphatikiza mafuta a sesame mu zakudya za anthu omwe ali ndi kuthamanga kwa magazi kumatha kukhala othandiza kuposa kuwapatsa mankhwala.

Zotsatirazi zidanenedwa ku American Heart Association pamsonkhano wapachaka wa Inter-American Society of Hypertension wolemba Pulofesa Devarajan Sankar waku Annamalai University, India.

 

ii. Kutsekedwa m'matumbo.

Kafukufuku wazotsatira za sesamol pamatumbo amatanthauza kuti zitha kukhala bwino kuposa aspirin. Pa kafukufuku wokhudzana ndi ulcerative colitis, IBD (yotupa matumbo), yomwe imawononga minofu ya mucosal kudzera pakuchepetsa dongosolo lotupa. Kafukufuku wokhudza makoswe, sesamol adapezeka kuti amachepetsa zochitika za michere yoyambitsa kutupa.

Ngakhale aspirin imadziwika kuti imapha matenda opatsirana ikamwa, imatha kubweretsa zilonda pakutha kwakanthawi. Aspirin amachititsa kuvulala kwam'mimba potulutsa maselo.

Kafukufuku wowonjezereka akuwonetsa kuti nasogastric intubation ya sesamol mwa odwala omwe ali ndi zotsekeka zazing'ono zazing'ono limodzi ndi chisamaliro chokhazikika zimachepetsa mwayi wochitidwa opaleshoni.

 

iii. Matenda a mtima.

Zowopsa zomwe zimayambitsidwa ndi matenda amtima zili ndi gawo lalikulu pakufa ndi kuwonongeka kwapadziko lapansi. Zitha kubweretsa kupsinjika kwa okosijeni ndipo ngati osachiritsidwa angawonjezeke ndikupanga mitundu yamafuta a oxygen, kuphatikiza njira zopewera zoteteza antioxidant.

Sesamol amagwiritsa ntchito anti-oxidative katundu wake kuti aletse atherosclectoric a mtima matenda a ziwopsezo monga hypercholesterolemia, hypertriglyceridemia, kutsika kwambiri kwa lipoprotein cholesterol komanso otsika kwambiri a lipoprotein.

Kafukufuku wowonjezera watsimikizira kuti sesamol ili ndi ziwalo zolimbitsa komanso kutsitsa kwamadzimadzi. Kuphatikiza apo, imateteza ku myocardium motsutsana ndi mtima wa mtima wa DOX.

 

IV. Kukula kwa ana.

Sesamol imagwiritsidwa ntchito pamitundu ingapo yakukula kwa mwana. M'maphunziro osiyanasiyana, sesamol yogwiritsira ntchito kuchepetsa ADHD mwa ana omwe ali ndi vuto lamaganizidwe amatchedwa othandiza ngati agwiritsidwa ntchito pang'ono. Kuperewera kwa DHA ndikofala kwambiri kwa ana omwe ali ndi ADHD.

Kafukufuku wopitilira khumi akuwonetsa maubwino abwino azizindikiro za ADHA kuphatikiza kuwerenga mawu, kutengeka, kuphunzira zowonera, kukumbukira ntchito, ndi kusachita chidwi.

Makanda atafikisidwa pa mafuta a sesame kwa milungu inayi adalemba kukula bwino komanso kulimbitsa thupi.

 

v. Matenda a shuga.

Sesamol imagwira ntchito bwino ngati chowonjezera ku mankhwala ashuga kuti ichepetse magazi msanga mwachangu. Kutenga mankhwala a sesamol kapena m'malo mwake kusunthira mafuta azitsamba mukamadwala matenda ashuga kumapereka zokolola zabwino pantchitoyo.

M'mafukufuku angapo, ambiri okhudza odwala matenda ashuga amtundu wa 2, sesamol awonetsa zotsatira zabwino. Chimodzi mwazofukufuku chimakhudza magulu atatu, lirilonse likudwala matenda ashuga amtundu wa 2. Gulu limodzi limagwiritsidwa ntchito ndi sesamol lokha, lina limamwa mankhwala a tsiku ndi tsiku a glibenclamide (Glyburide), ndipo omaliza ku sesamol ndi Glyburide pafupifupi milungu 7.

Sesamol akuti anali ndi mphamvu yolumikizirana ndi glyburide, chifukwa mankhwala ophatikizirawa adachepetsa hemoglobin A1c komanso kuchuluka kwa shuga m'magazi kwambiri, komanso bwino kuposa mankhwala amodzi.

Hyperlipidemia. Ofufuzawo akuti sesamol yomwe imagwiritsidwa ntchito kuwotcha mafuta a cholesterol ndi ma lipids ena m'magazi yapereka zotsatira zabwino. Poyesa koyeserera, mphamvu ya sesamol inayesedwa pa mafuta a hyperlipidemia, hyperlipidemia, hypercholesterolemia, ndi hyperlipidemia.

Kuchepetsa milingo ya triacylglycerol momwe zotsatira zake zimatsimikizira kuti sesamol imachepetsa kuyamwa kwa triacylglycerol. Sesamol imagwiritsidwanso ntchito kuthana ndi mafuta okwera kwambiri.

Kafukufuku akuwonetsa kuti sesamol supplement imakulitsa kutulutsa kwa cholesterol komanso kumachepetsa kuyamwa kwake.

 

VI. Matenda amadzimadzi ndi kunenepa kwambiri.

Sesamol akuti ili ndi zida zosiyanasiyana zachilengedwe kuphatikiza kuthekera kobwezeretsa kunenepa kwambiri komanso zovuta zamagetsi. Amanenedwa kuti amalepheretsa kunenepa kwambiri.

Kafukufuku wopangidwa kuti ayese momwe sesamol ilili ndi kunenepa kwambiri, zidapezeka kuti zitha kuyambitsa kagayidwe kake ka lipid kagayidwe kake. Izi zidapangitsa kuti insulin isagwiritsidwe ntchito komanso kuchepa thupi. Kunenepa kwambiri komanso zovuta zake zokhudzana ndi kagayidwe kazinthu zimagwirizana kwambiri ndi kuchuluka kwa lipid m'thupi. Kuchepetsa kudzikundikira kumatanthawuza kusintha kwa kunenepa kwambiri.

Kugwiritsa ntchito Sesamol kumawonjezera lipolysis, mafuta asidi makutidwe ndi okosijeni ndi kuchepa kwa chiwindi lipogenesis, zinthu zofunika kwambiri kutsitsa zamadzimadzi kudzikundikira. Izi (mwachitsanzo, kutenga lipid, kaphatikizidwe ndi katemera) ndi zina mwazomwe zimachitika pachiwindi.

Anthu omwe amagwiritsa ntchito sesamol adanenanso za mbiri yabwino ya hepatic ndi serum lipids, komanso adalimbikitsa chidwi cha insulin.

 

vii. Matenda a nyamakazi, Osteoarthritis, ndi kufooka kwa mafupa.

Ngakhale nyamakazi ya nyamakazi, matenda opweteka komanso osachiritsika omwe ali ndi autoimmune, ali ndi zochiritsira zingapo zamankhwala, kugwiritsa ntchito kwawo kwanthawi yayitali nthawi zambiri kumakhala hepatotoxic. Sesamol atha kukhala njira yachilengedwe yothetsera. Kafukufuku wofufuza zomwezi adanenanso kuti sesamol ili ndi zotsatira zabwino za anti-arthritic and anti-inflammatory zomwe zimapangitsa kuti matenda a nyamakazi asinthe.

Osteoarthritis ndichinthu chachikulu chomwe chimapangitsa kuti mafupa agwirizane, akuti akukhudza pafupifupi 15% ya anthu padziko lonse lapansi. Kupsinjika kwa oxidative, komabe, kumathandizira kwambiri pakufooka kwa mafupa. Kafukufuku wokhudzana ndi sesamol pamankhwala ophatikizana a osteoarthritis adawonetsa kuti kumwa sesamol supplement kwa sabata limodzi kumatha kuchepetsa kupweteka. Izi zimachitika chifukwa cha anti-oxidative stress katundu wa sesamol.

Asayansi apeza kuti njira yofananayi ndi postmenopausal osteoporosis yatha kuyambitsa ovariectomy, komwe kumachepetsa kuchepa kwa mafupa ndi mphamvu. Chifukwa chake zimapezeka kuti kutayika kwa mafupa kumachitika chifukwa cha estrogen. Sesamol akuti amamangirira ma estrogen receptors ndikupangitsa kuti majini amveke amtundu wa estrogen. Zopindulitsa zimalimbikitsa mphamvu ya mafupa popanga mapuloteni amtundu wa mafupa.

 

viii. Matenda a Alzheimer, nkhawa komanso sitiroko.

Matenda a Alzheimer's ndimatenda opitilira ubongo omwe amayamba chifukwa cha kuchepa kwamaselo aubongo. Nthawi zambiri zimathetsa kudziyimira pawokha kwa anthu omwe akhudzidwa. Zotsatira za neuroprotective za sesamol zakhala zikulonjeza. Kafukufuku adapangidwa kuti afotokozere kuthekera kwa mankhwala a sesamol mu khunyu, vuto lomwe limalumikizidwa kwambiri ndi kusokonezeka kwa chidziwitso komanso kupsinjika kwa oxidative. Kafukufukuyu adatsimikiza kuti sesamol idakhala ndi zovuta pakukhudzidwa, kufooka, kuzindikira, komanso kupsinjika kwa oxidative. Kugwiritsa ntchito Sesamol mankhwala a antiepileptic kungakhale kopindulitsa.

 

Sesamol amapindula

[a]. Sesamol Anti-oxidant zotsatira

Kupsinjika kwa oxidative kumachitika pakakhala kusalinganirana kwa kupanga kwaulere ndi ma antioxidants mthupi. Izi nthawi zambiri zimabweretsa kuwonongeka kwa ma cell ndi kupsinjika kwa oxidative kumawonedwa ngati komwe kumayambitsa zovuta zambiri.

Kupsinjika kwa okosijeni ndi njira yachilengedwe yomwe imathandiziranso kukalamba.

Antioxidants mbali ina ndi zinthu zomwe zimalepheretsa kuwonongeka kwa maselo chifukwa cha zopitilira muyeso zaulere. Iwo amatchedwa ufulu ankafuna kusintha zinthu mopitirira scavengers.

Sesamol ndiye gawo lamphamvu kwambiri komanso lamphamvu kwambiri la antioxidant yamafuta a sesame. Imagwira ntchito m'njira zosiyanasiyana kuti ipereke antioxidant zotsatira. Njirazi zimaphatikizapo kukhazikitsa-ntchito zofunikira za antioxidant, kuteteza DNA ku kuwonongeka kwa radiation, kuwononga zopangira zaulere, kuletsa kulowetsedwa kwa lipid, ndi kutetezedwa ku radiation ya ultraviolet.

Kafukufuku wowunika zochitika za radiation za sesamol motsutsana ndi gamma walitsa mu DNA. Kuwonongeka kwa DNA kumayambitsidwa chifukwa chokhazikitsa njira imodzi kapena iwiri yopingasa kudzera pakupanga mitundu yama oxygen.

Sesamol idapezeka kuti imalepheretsa kusweka kwa DNA komwe kumangokhala limodzi. Zidachepetsanso kuchuluka kwa zopitilira muyeso makamaka ma hydroxyl, DPPH, ndi ABTS radicals, zomwe zonse zimalumikizidwa ndi zopumira zomwe zidaphatikizidwa kamodzi kapena kawiri.

 

[b]. Sesamol Anti-yotupa ubwino

Kutupa ndimachitidwe achilengedwe omwe thupi limagwiritsa ntchito kulimbana ndi othandizira akunja monga mabakiteriya, bowa, kapena ngakhale kuvulala. Komabe, kutupa kwakanthawi kovulaza kumawononga thupi chifukwa kumabweretsa zovuta zosiyanasiyana.

Ma anti-inflammatory agents amateteza thupi kuti lisawonongeke polimbana ndi kutupa. Sesamol imagwira ntchito m'njira zosiyanasiyana popereka zotsutsana ndi zotupa. Njirazi zimaphatikizapo kuletsa maselo otupa, kuchepetsa kupanga ma nitrites komanso kupondereza zochitika ndi njira zotupa.

Pofufuza makoswe okhala ndi lipopolysaccharide LPS-omwe amachititsa kuvulala kwamapapu, sesamol adapezeka kuti akupondereza ma cytokines odana ndi zotupa komanso amalepheretsa kupanga nitric oxide ndi prostaglandin E2 (PGE2). Sesamol idapezekanso kuti ikukhazikitsa kuyambitsa kwa adenosine monophosphate-activated protein kinase (AMPK). Izi zimathandiza kupewetsa kutupa komanso kuchepetsa kuwonongeka kwa maselo.

[c]. Khansa yotsutsana ndi Sesamol zotsatira

Sesamol ili ndi zinthu zomwe zimathandiza kuthana ndi ma cell a khansa kuphatikiza ntchito zotsutsana ndi kufalikira kudzera munjira zosiyanasiyana monga kuletsa kuthekera kwa nembanemba, kumanga kukula kwamaselo magawo osiyanasiyana komanso kuchititsa kuti apoptosis isapitirire.

Pakafukufuku wophatikizapo DLD-1 cell cell ya khansa yamtundu wa anthu, sesamol idagwiritsidwa ntchito pamlingo wa 12.5-100 μM. Zinapezeka kuti ntchito zolembedwa ndi COX-2 zidatsika ndi 50%.

Pakafukufuku wina, sesamol yomwe imagwiritsidwa ntchito pamlingo waukulu wa 0.5-10 mM idapezeka kuti imapangitsa apoptosis mu HCT116 powonjezera okosijeni wama cell opatsirana (O2 • -) m'njira yodalira mlingo. Izi zidapangitsa kuti njira yolembetsera JNK iyambitsidwe yomwe imalimbikitsa kuwonongeka kwa mitochondrial. Izi zimatulutsanso cytochrome c yomwe pamapeto pake imayambitsa vuto lomwe limapangitsa kuti apoptosis isokonekere.

 

[d]. Nyanja Anti-mutagenic zotsatira

Mutagenicity amatanthauza kuthekera kwa wothandizila (mutagen) kuyambitsa masinthidwe. Kusintha komwe ndikusintha kwa majini kumatha kubweretsa kuwonongeka kwama cell ndipo kumaganiziridwa kuti kumayambitsa matenda ena monga khansa.

Sesamol yasonyezedwa kuti ili ndi zida zotsutsana ndi mutagenic. Zopindulitsa zake zotsutsana ndi mutagenic zimachokera ku ntchito ya antioxidant komanso makamaka kuthekera kowononga zopitilira muyeso zaulere.

Pakafukufuku, mutagenicity idayambitsidwa ndi kupangika kwa zopitilira muyeso za oxygen ndi tert-butylhydroperoxide (t-BOOH) kapena hydrogen peroxide (H2O2). Sesamol anapezeka kuti ali ndi mphamvu zotsutsana ndi mutagenic pamavuto oyesera a Ames TA100 ndi TA102. Kupsyinjika kwa TA102 kumadziwika kuti kumakhudzidwa kwambiri ndi mitundu yama oxygen yomwe imagwira ntchito. Sesamol adawonetsedwanso kuti amaletsa mutagenicity ya sodium azide (Na-azide) mumayeso a TA100 oyesa.

 

[e]. Sesamol Protection kuchokera ku radiation

Magetsi amatanthauza mphamvu yomwe imayenda ngati mafunde kapena tinthu tating'onoting'ono. Magetsi amatha kuchitika kwambiri m'dera lathu. Komabe, cheza cha ionizing chitha kukhala chowopsa ngati sichingasinthidwe. Kuwonetsedwa pang'ono kwa radiation kumatha kubweretsa matenda oyipa monga radiation radiation ndi kutentha kwa dzuwa.

Kuwonjezeka kwa ma radiation kumayambitsa zovuta zazikulu kuphatikiza khansa ndi matenda amtima.

Pofufuza mbewa zomwe zimapangitsa kuti DNA iwonongeke poizoniyu, sesamol inayesedwa chifukwa chodziteteza ku radiation. Kuchulukitsa mbewa ndi sesamol kudadzitchinjiriza ku kuwonongeka kwa DNA komwe kumayambitsa ma radiation.

 

[f]. Mtima

Sesamol akuti amateteza mtima kuvulala.

Pakafukufuku wofufuza zoteteza za sesamol motsutsana ndi kuvulala kwam'mimba, sesamol prereatment idaperekedwa pa (50 mg / kg) idachitidwa masiku 7 nthawi ya opareshoni isanachitike.

Kafukufukuyu adazindikira kuti sesamol idachepetsa kwambiri kukula kwa infarct, idagwiritsa ntchito zolembera zamtima, inaletsa lipid peroxidation, kulowa kwa neutrophil komanso kukweza ma antioxidants level. , komanso inalimbikitsa ntchito ya anti-apoptotic Bcl-3 protein.

 

[g]. Sesamol Otsutsa aulere akusakaza

Ma radical aulere ndi ma atomu osakhazikika omwe amapeza ma electron mosavuta kuchokera kumaatomu ena. Zonsezi ndizopindulitsa komanso ndi poizoni kutengera kukhazikika kwawo. Pazigawo zochepa, ma radicals aulere amatenga gawo pamagwiridwe antchito amthupi, komabe, akakhala kuti amakhala ochuluka kwambiri amakhala ovulaza. Zowononga zaulere zimapanga kupsinjika kwama oxidative komwe kumatha kuwononga maselo ndipo kumatha kubweretsa zovuta zambiri zosafunikira monga khansa, matenda amtima, nyamakazi, cataract, ndi matenda amanjenje.

Matupi athu amalimbana ndi zovuta zakuthupi popanga ma antioxidants komabe mwina sangakhale okwanira ndipo amafunikira zowonjezera kudzera muzakudya kapena zowonjezera.

Sesamol ali ndi kuthekera koletsa kupangika kwa zopitilira muyeso komanso kuwononga zopanda pake zaulere.

Kafukufuku wokhudzana ndi khungu lamunthu lamankhwala a khungu lamankhwala a fibroblast achikulire (HDFa) opezeka ndi UVB, sesamol prereatment idayesedwa motsutsana ndi cytotoxicity, intacellular reactive oxygen species (ROS), lipid peroxidation, antioxidant status, komanso oxidative DNA kuwonongeka. Sesamol anapezeka kuti amachepetsa kwambiri lipid peroxidation, cytotoxicity, ROS, ndi kuwonongeka kwa okosijeni mu khungu la khungu la munthu. Izi zimachitika chifukwa cha kuthekera kwa sesamol yowonjezerapo ROS.

Kafukufuku omwewo adanenanso zakukula kwa ma enzymatic komanso osagwiritsa ntchito ma enzymatic zomwe zimapangitsa kuti ntchito ya antioxidant ikhale yabwino.

 

[h]. Amachepetsa cholesterol yamagazi

Cholesterol wamagazi ndimafuta onga mafuta, m'thupi lanu. Ndikofunikira kuti thupi limange ma cell abwinobwino koma moyenera. Cholesterol imanyamulidwa pamitundu iwiri ya lipoprotein, kachulukidwe kotsika, komanso kachulukidwe kake. Chifukwa chake imabweretsa mitundu iwiri ya cholesterol, cholesterol yotsika kwambiri ya lipoprotein (LDL), ndi cholesterol yochulukitsitsa ya lipoprotein (HDL).

LDL nthawi zambiri amatchedwa cholesterol yoyipa kuyambira LDL yambiri onjezerani chiopsezo chanu chamatenda amitsempha ndi matenda ena.

Sesamol imatha kutsitsa kuchuluka kwa cholesterol komanso mulingo wa triacylglycerol mthupi.

Muyeso lolekerera mafuta, sesamol (100 ndi 200 mg / kg) anapezeka kuti kwambiri (P <0.05) amachepetsa kuyamwa kwa triacylglycerol motero kutsitsa mulingo wa triacylglycerol mthupi. Triacylglycerol ndiye gawo lalikulu la mafuta omwe amasungidwa mu minofu ya adipose.

Pofufuza mbewa za ku Switzerland za albino zomwe zimayambitsa matenda a hyperlipidemia, othandizira a sesamol pa 50 ndi 100 mg / kg akuti adachepetsa kwambiri cholesterol ndi triacylglycerol kwambiri.

Ntchito ya sesamol yochepetsa cholesterol ndi milingo ya triacylglycerol imadziwika kuti imatha kuchepetsa kuyamwa komanso kuwonjezera kutulutsa kwa cholesterol.

 

[i]. Sesamol amapindulitsa khungu

Khungu la munthu ndi gawo limodzi lamaumboni omwe ntchito yawo yayikulu ndikuteteza ziwalo za thupi.

Sesamol amapindulitsa khungu m'njira zosiyanasiyana chifukwa cha mphamvu zake kuphatikizapo antioxidant, ndi anti-inflammatory activity. Sesamol amapindulitsa khungu ndi

 

· Kuteteza khungu ku cheza cha ultraviolet (UV)

Kuwonetsedwa ndi kuwala kwa dzuwa nthawi yayitali kumatha kubweretsa mitundu yolemera kwambiri ya oxygen (ROS), yomwe imatha kuwononga khungu monga kuwonongeka kwa collagen mu dermis ndi hyperplasia ya epidermis.

Sesamol imatha kupukusa zopangira zaulere zomwe zimachitika chifukwa chakuwala kwakutali kwa dzuwa motero zimateteza khungu ku kuwonongeka kwa ma radiation ya DNA. Amapereka zokutira zoteteza zomwe zimathandiza kuti khungu lisawonongeke ndi cheza cha UV.

Kafukufuku akuti sesamol imatha kuchepetsa cytotoxicity yochokera ku UVB. Amanenanso kuti amaletsa melanin biosynthesis pochepetsa mawu a tyrosinase, MITF, TRP-1, TRP-2, ndi MC1R m'maselo osungunuka.

Kafukufuku wina adapeza kuti sesamol itha kulepheretsanso kaphatikizidwe ka melanin poyambitsa kampeni / protein kinase A (cAMP / PKA), protein kinase B (AKT) / glycogen synthase kinase 3 beta (GSK3β) / CREB, TRP-1, ndi MITF ku B16F10 maselo

 

· Thandizani kukhala ndi khungu lowala

Sesamol amadziwika kuti ndi antioxidant wamphamvu. Amalowa pakhungu motero ndikuthandizira khungu. Izi zimathandizanso kupeza khungu lowala.

 

· Imachotsa ziphuphu

Ziphuphu zimakhala ngati zotupa pakhungu zimadzaza ndi mafuta, dothi, komanso tizilombo tina tangozi.

Sesamol ali ndi ma antibacterial omwe amawathandiza kuti athetse tizilombo toyambitsa matenda kotero kuti mumakhala opanda khungu.

 

· Amapereka zotsutsana ndi ukalamba

Kukalamba ndi njira yapakatikati komanso yopitilira moyo. Komabe kukalamba msanga kumatha kuchitika chifukwa cha zinthu zingapo monga kuwonekera kwakanthawi pamawala a UV, kupsinjika kwa oxidative pakati pa ena.

Sesamol imapereka ntchito yoteteza antioxidant yomwe imalepheretsa khungu ndi thupi kuchokera ku ma oxidation am'manja komanso imathandizira kukonzanso khungu.

Sesamol inanenedwa kuti imalepheretsa kupezeka kwa mizere, pores, ndi makwinya.

 

[j]. Sesamol amapindulitsa tsitsi

Kugwiritsa ntchito mafuta a sesame kumapatsa thanzi kumutu, tsitsi, komanso shaft. Izi zimalimbikitsa kukula kwa tsitsi. Zimathandizanso kuchiritsa khungu lililonse lomwe lawonongeka ndi mankhwala panthawi yokometsera tsitsi kapena kupaka utoto.

Kumeta tsitsi msanga kumatha kuchitika chifukwa chakuchepa kwa thupi kupanga melanin yokwanira, komanso zinthu zina monga kupsinjika kwa okosijeni, kusintha kwa majini monga zakudya komanso kugwiritsa ntchito mankhwala osokoneza bongo.

Sesamol supplement yatsimikizira kuti imatha kusunga utoto wamtundu komanso kudetsa tsitsi laimvi kale.

Kuphatikiza apo, sesamol imatha kuthana ndi vuto. Kutupa kumatha kuchitika chifukwa cha khungu louma, zovuta zomwe zimapangidwa ndi zinthu za tsitsi, komanso kukula kwa bowa pamutu pazinthu zina. Sesamol amathandizira kudyetsa khungu motero amakhala ndi khungu labwino motero amalepheretsa kupezeka kwa dandruff. Ntchito ya antibacterial imatsimikiziranso kuti khungu la mutu lilibe tizilombo tomwe timayambitsa matenda.

 

Njira zitatu zopangira sesamole

①. Kuchokera ku mafuta a Sesame

Sesamol Kuphatikiza kuchokera ku mafuta a Sesame ndiye njira yosavuta kwambiri mwanjira zitatu izi. Komabe, ndizokwera mtengo kwambiri. Chifukwa chake njirayi siyabwino pakupanga mafakitale, makamaka chifukwa chokwera kwambiri.

 

②. Kupanga komwe kumachokera ku piperamine

Ngakhale ndizachuma mwachimodzimodzi pamlingo waukulu wa Sesamol Production, njira yonse ya masamu kuphatikiza kuchokera ku piperamine imagwiranso ntchito popanga kanthu kakang'ono pamene ntchito ya hydrolysis ndi hydrolysis ikugwira ntchito. Zikatero, mapangidwe a pigment chifukwa chogwirizanitsidwa komanso zotsatira zake sizingalephereke.

 

③. Njira yopangira theka yochokera ku jasmonaldehyde

Njira yopanga yochokera ku jasmonaldehyde ndiyo njira yogwiritsidwa ntchito kwambiri posakaniza synthes monga momwe mafakitale akukhudzira. Mchitidwewu umaphatikizapo oxidation ndi hydrolysis ndipo chifukwa cha izi, sesame phenol yoyambira ndi yapamwamba komanso yapamwamba kwambiri.
Njirayi imagwiritsa ntchito ukadaulo wosakaniza komanso wotulutsa zida wokwera mtengo, zomwe zimapangitsa kupatukana kwachangu kwazinthuzo kuchokera m'zigawo. Izi zimachepetsa kuthekera kwakomwe kuchitapo kanthu mbali. Nzosadabwitsa kuti chomaliza chomaliza (choyera ngati kristalo) ndichabwino kwambiri potengera mtundu ndi sesamol kachulukidwe.

 

Ali kuti gulani sesamol

Sesamol ufa amapezeka pa intaneti kuchokera kosiyanasiyana opanga sesamol. Ambiri ogwiritsa ntchito sesamol amagula mosiyanasiyana Websites, ena amagulitsa kapena kugulitsa.

Tsimikizani kuvomerezeka kwa chilichonse wopanga sesamol kugwiritsa ntchito malamulo amchigawo musanagule.

 

Zothandizira

1. Joo Yeon Kim, Dong Seong Choi ndi Mun Yhung Jung "Antiphoto-oxidative Activity ya Sesamol ku Methylene Blue- ndi Chlorophyll-Sensitized Photo-oxidation ya Mafuta" J. Agric. Chakudya Chem., 51 (11), 3460 -3465, 2003.
2. Kumar, Nitesh & Mudgal, Jayesh & Parihar, Vipan & Nayak, Pawan & Nampurath, Gopalan Kutty & Rao, Chamallamudi. (2013). Kuchiza kwa Sesamol Kumachepetsa Plasma Cholesterol ndi Triacylglycerol Levels mu Mouse Models of Acute and Chronic Hyperlipidemia. Lipids. Onetsani: 48. 633-638. Onetsani: 10.1007 / s11745-013-3778-2.
3. Majdalawieh, AF, & Mansour, ZR (2019). Sesamol, lignan wamkulu mu nthangala za sesame (chizindikiro cha Sesamum): Ma anti-khansa katundu ndi njira zake. European Journal of Pharmacology, 855, 75-89.CHINSINSI: 10.1016 / j.ejphar.2019.05.008.
4. Osawa, Toshiko. "Sesamol ndi sesamol monga antioxidants." Makampani Atsopano a Zakudya (1991), 33 (6), 1-5.
5. Sesamol Yosungidwa 2010-01-14 ku Wayback Machine ku Chemicalland21.com
6. Wynn, James P .; Kendrick, Andrew; Ratledge, Colin. "Sesamol monga choletsa kukula komanso kagayidwe kake ka lipid mu Mucor circinelloides kudzera pamagetsi a michere." Lipids (1997), 32 (6), 605-610.